立体定向伽玛刀治疗功能性垂体腺瘤  

Stereotactic gamma knife treatment of functional pituitary adenomas

作　　者：孟喜君[1] 李文涛[1] 刘守勋[1] 夏明[1] 

机构地区：[1]西安交通大学医学院第一附属医院伽玛刀中心,西安710061

出　　处：《陕西医学杂志》2007年第12期1617-1619,共3页Shaanxi Medical Journal

摘　　要：目的:探讨对伽玛刀治疗功能性垂体腺瘤的疗效及相关因素。方法:回顾性分析伽玛刀治疗的412例功能性垂体腺瘤患者的临床资料。其中207例为PRL型,89例GH型,46例为ACTH,70例为混合型;肿瘤所接受的平均边缘剂量分别为30.6Gy、22.1Gy、34.5Gy、和21.7Gy。结果:平均随访时间为24个月,90例(40.2%)内分泌恢复正常,119例(53.1%)下降,无变化或升高15例(6.7%),84例肿瘤消失,117例(52.2%)肿瘤缩小,1例(0.4%)增大。结论:伽玛刀治疗功能性垂体腺瘤是安全有效的方法,不仅能控制肿瘤生长,而且能使内分泌功能大部分恢复正常。Objective： To evaluate the effect and the factors associated with gamma knife treatment for functional pituitary adenomas. Methods： Between June 1999 and June 2005,412 cases of functional pituitary adenoma were treated by gamma knife. 224 cases were followed up. Among them, 207 there were patients with prolactin （PRL）-producing tumors. 89 patients with growth homone （GH）- producing tumors. 46 patients with adrenocorticotrophic （ACTH）-producing tumors. 70 patients with tumors that secreted both PRL and GH. The mean marginal dose was 30. 6Gy, 22.1Gy, 34.5Gy and 21. 7Gy respectively. Results： The mean following-up time was 24 months. In 90 cases （40.2%） there was normalization of hormone secretion after gamma knife treatment. The hormonal level was reducted in 119 （53. 1%） patients. In 15 patients（6. 7%） there was no significant change. In radiological follow up 84 cases showed no tumor, in 117（52. 2%） cases the tumor reduced in size, in 1 case（0. 4%） the tumor increased in 1 case. Conclusion： Gamma knife radiosurgery is an effective and safe therapy both in tumor volume control and in hormone control.

关 键 词：垂体肿瘤/外科学 放射外科手术 Γ射线 

分 类 号：R736.4[医药卫生—肿瘤]