晕船适应过程中大鼠铁吸收的变化  

Change of absorption in iron during seasickness adaptation in rats

作　　者：李娜[1] 郭俊生[1] 秦海宏[1] 陈建波[1] 

机构地区：[1]第二军医大学海医系军队卫生学教研,上海200433

出　　处：《中华航海医学与高气压医学杂志》2007年第5期282-284,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：海军医学专项基金（HGG2005-05）

摘　　要：目的探讨晕船对大鼠铁吸收的影响。方法雄性SD大鼠20只，按完全随机方法分为正常对照组和晕船组。晕船组大鼠每天给予模拟晕船刺激2h，连续14d。以大鼠异嗜高岭土行为作为评价其运动病发生的指标。正常对照组大鼠不给予旋转刺激。记录大鼠每日高岭土取食量和吸收量，并收集两组大鼠第1、3、7、14天的粪便。通过原子吸收分光光度计测量并计算大鼠摄入和排出的铁总量，并计算铁的表观吸收率。结果晕船组大鼠异嗜高岭土的量显著高于对照组（P〈0.01），两组大鼠进食量无差异，晕船大鼠第7天粪便铁排出量显著增高（P〈0.05），铁的表观吸收率显著低于对照组（P〈0．05）。结论晕船刺激在一定的时间内能够阻碍大鼠对铁的吸收。Objective To investigate effect of seasickness on absorption in iron in rats. Methods Twenty male Sprague - Dawley rats were randomly divided into control group and seasickness group. The rats in seasickness group were given simulation seasick stimulus two hours a day and did so for 14 successive days. Behavior of pica kaolin in rats was regarded as index of motion sickness. The rats in control group were not given simulation seasick stimulus. Appetite and absorbed dose of kaolin in rats were recorded daily. And stools of rats in the two groups were collected on day 1, day 3, day 7, day 14. The iron content of absorption and egestion were measured by atomic absorption spectrophotometer. Then the apparent absorption rate of rats would be calculated. Results The rats in seasickness group had significantly better appetites for kaolin than those in control group （ P 〈 0.05 ）. There was no significant difference between intake quantity of the two groups. The iron content in feces on day 7 in seasickness group was significantly higher than that in control group （ P 〈 0. 05） ,while the apparent absorption rate on day 7 in seasickness group was significantly lower than that in control group（P 〈0.05）. Conclusions Seasick stimulation in a certain period can interfered with absorption in iron.

关 键 词：晕船 大鼠 铁 表观吸收率 代谢平衡实验 

分 类 号：R[医药卫生]