菊米提取液抗实验性心律失常作用的研究  

EXPERIMENTAL STUDIES ON ANTIARRHYTHMIC EFFECT OF JUMI EXTRACTION

作　　者：徐策[1] 叶挺梅[2] 朱立[1] 陈莹莹[1] 沈岳良[1] 

机构地区：[1]浙江大学医学院生理学教研室,浙江杭州310058 [2]丽水学院化学与生命科学院生物系,浙江丽水323000

出　　处：《中国应用生理学杂志》2007年第4期399-402,共4页Chinese Journal of Applied Physiology

基　　金：浙江省科技厅基金资助项目(2004C33104)

摘　　要：目的:观察菊米提取液对氯仿、乌头碱和缺血诱发的心律失常的作用。方法:采用氯仿诱导小鼠心律失常,静脉注射乌头碱和冠脉结扎法诱导大鼠心律失常,术前5d给予菊米提取液,记录心电图曲线。结果:菊米提取液能剂量依赖性地明显降低氯仿诱导的小鼠室颤发生率。与对照组相比,奎尼丁可明显减少乌头碱(30μg/kg)诱导的大鼠室性早搏和室性心动过速的发生次数,缩短心律失常的持续时间。但菊米提取液组对乌头碱诱导的大鼠心律失常无明显作用。高浓度菊米提取液(2.0g/kg)可明显降低缺血复灌性心律失常评分。但低、中浓度菊米提取液(0.5g/kg和1.0g/kg)对缺血心脏心律失常评分无明显作用。结论:菊米提取液可对抗氯仿和缺血诱导的实验性心律失常,但对乌头碱引发的心律失常无影响。To investigate the antiarrhythmic effect of Jumi were used, Results： Administration of JM extraction reduced （JM） extraction. Methods： The conventional antiarrhythmic methods the occurrence of ventricular fibrillation induced by chloroform in a dosedependent manner in mice. Quinidine significantly decrea,sed the number of ventricular premature beats and ventricular tachycardia, shortened the duration of arrhythmia in conitine-treated rats. But JM extraction had no effect on conitine-induced arrhythmia. Compared with control, arrhythraia score was lower in ischemia/reperfusion rats which pretreated with 2.0 g/kg of JM extraction. Conclusion： JM extraction has obvious protection effects in chloroform- and ischemia-induced arrhythmia, but has no effect in conitineqnduced arrhythmia.

关 键 词：菊米提取液 心律失常 氯仿 乌头碱 缺血 

分 类 号：Q463[生物学—生理学]