低剂量5-氟尿嘧啶持续静注联合顺铂、周剂量多西紫杉醇治疗晚期胃癌  

Clinical study of continuous venous infusion of low-dose 5-Fu and cisplatin combined with weekly docetaxel for treatment of advanced gastric cancer

作　　者：李小琴[1] 顾汉刚[1] 郭建伟[1] 朱小霞[1] 

机构地区：[1]江苏大学附属医院肿瘤治疗中心,江苏镇江212001

出　　处：《现代肿瘤医学》2007年第5期659-661,共3页Journal of Modern Oncology

摘　　要：目的:观察低剂量5-氟尿嘧啶(5-Fu)持续静注联合顺铂(DDP),周剂量多西紫杉醇(DOC)即FPD方案治疗晚期胃癌的疗效和毒性。方法:60例晚期胃癌患者随机分成两组,A组30例用FPD方案:5-Fu 200mg.m-2.d-1,经静脉微量泵持续24h注射,DDP 6mg.m-2.d-1,静滴1h,每周5d,DOC 25 mg.m-2.w-1静滴,均连用3周。B组30例应用低剂量5-Fu持续静注联合DDP(FP)方案,具体用法同A组。两组均以21d为1个疗程,间隔1周重复,2个周期后评定疗效。结果:A、B两组近期有效率分别为73.3%(22/30)及63.3%(19/30);中位无进展时间分别为4.8个月及2.6个月;中位生存期分别为9个月及5个月。两组无与化疗药物毒性有关死亡,毒副作用较轻。A组主要剂量限制性不良反应为骨髓抑制,Ⅲ/Ⅳ度白细胞减少占13.3%(4/30),无Ⅲ/IV度血小板及血红蛋白下降。非血液毒性主要是消化道反应和脱发。而对照组B组有轻度骨髓抑制及消化道副反应,无Ⅲ/IV度血液毒性及其他严重副反应。结论:FPD方案治疗晚期胃癌近期疗效较好,毒副反应较小,是较为理想的方案。Objective： To evaluate the efficacy and toxicity of continuous venous infusion of low - dose 5 - Fluorouracil（5 -Fu） and cisplatin （DDP）combined weekly docetaxel（DOC） in advanced gastric cancer. Methods：Total of 60 cases with advanced gastric cancer were included in the study. For group A （30 cases）, the regimen of FPD was consisted of 5 - Fu 200mg. m^-2. d^-1 ,civ,DDP 6 mg. m-2. d^-1 ,iv gtt ,5 day every week,and docetaxel 25 mg.m^-2^ . w ^-1,iv gtt, which were used for 3 weeks. For group B （ 30 cases）, was treated with continous venous infusion of low - dose 5 - Fu and cisplatin （FP） regimen. The same schedule for both groups was repeated every 28 days,with two cycles for all patients. The evaluation of disease status was made after two cycles. Results： The recent response rates of group A and group B were 73.3% （22/30） and 63.3% （19/30） ,respectively. The median time to progression （TTP） was 4.8 months for group A and 2.6 months for group B. The median survival was 9 months for group A and 5 months for group B. The main toxicity of group A was hematological： Grade m/IV leukopeniawas 13.3% （4/30）. The non - hematological toxicity of group A was gastrointestinal tract reaction and alopecia. The main toxicity of group B was mild luekopenia and gastrointestinal. No severe side effects occurred in any of the cases. Concliusion： FPD regimen mentioned above was a considerable regimen for patients with advanced gastric cancer.

关 键 词：胃癌 5-氟尿嘧啶 顺铂 多西紫杉醇 

分 类 号：R735.2[医药卫生—肿瘤]