35例中国人Cronkhite-Canada综合征临床分析  

Clinical characteristics of Cronkhite-Canada syndrome in Chinese:meta-analysis of 35 cases

作　　者：曹晓沧[1] 周斌 丁娟娟[1] 连佳[1] 陆宁[1] 王邦茂[1] 

机构地区：[1]天津医科大学总医院消化科,300052 [2]Cardiovascular Department of Children's Hospital Boston of Harvard Medical School USA

出　　处：《中华医学杂志》2007年第44期3130-3132,共3页National Medical Journal of China

摘　　要：目的分析中国人 Cronkhite-Canada 综合征(CCS)临床特点。方法在 PubMed 和中国医学文献数据库中检索1985至2006年中国人 CCS 临床资料并进行回顾性分析。结果发现35例中国人病例,患者以胃肠道多发息肉伴外胚层三联征为主要表现,慢性腹泻、腹痛、体重下降、贫血、水肿等症状最为常见,2例患者合并癌变。综合治疗可使部分患者症状得到不同程度"缓解"。该病呈现一定的种族及地区聚集性,但常被忽视。胃肠核素显像、双气囊小肠镜和胶囊内镜等新技术的应用为了解该病提供了新的信息。结论中国人病例与英、日文文献报道病例的临床特点基本相近。新技术的应用、报道项目的规范化以及数据共享有助于对该罕见病的深人了解。Objective To investigate the clinical characteristics of Chinese patients with Cronkhite- Canada syndrome （CCS）. Methods Relevant data of Chinese CCS patients from 1985 to 2006 were retrieved from Medline and Chinese biomedical database and a meta-analysis was conducted. Results A total of 35 CCS cases had been reported by Chinese hospitals with the clinical characteristics of gastrointestinal polyposis with ectodermal trilogy, mainly manifested as diarrhea, bellyache, weight loss, anemia, and edema. Canceration was reported in 2 patients. Some patients had symptomatic response to combination therapy. There might be racial or regional differences in CCS susceptibility; however, such information was often neglected in the medical records at home and abroad. New techniques, such as ^99Tc^m-HSA scan, double-balloon enteroscopy and wireless capsule endoscopy provided new information on CCS. Conclusion The clinical features of Chinese CCS patients are similar to those of the European or Japanese patients. Novel appliance, case report standardization and sharing database may promote the understanding of this rare syndrome.

关 键 词：综合分析 CRONKHITE-CANADA综合征 中国人 症状 诊断 

分 类 号：R735[医药卫生—肿瘤]