紫杉醇联合化疗同步放射治疗局部晚期宫颈癌的临床研究  

Paclitaxel-based Chemotherapy Combined with Concurrent Radiotherapy for Locally Advanced Cervical Cancer

作　　者：吴双[1] 彭瑛[1] 李志琳[1] 杨家林[1] 樊林[1] 王冀川[1] 文浩[1] 

机构地区：[1]四川省肿瘤医院放射科,成都610041

出　　处：《四川肿瘤防治》2007年第4期270-272,共3页Sichuan Journal of Cancer Control

摘　　要：目的:观察紫杉醇加顺铂联合同步放疗局部晚期宫颈癌的疗效和毒副反应。方法:Ⅱb~Ⅲb期宫颈癌患者60例随机分为两组,治疗组30例采用同步放化疗,对照组30例单纯放疗,两组放疗方法均相同,先行盆腔外照射;总剂量56Gy^60Gy/28次~30次,再行腔内后装:60Co腔内后装机,A点剂量6Gy/次,1次~2次/周,共3次。化疗方案:紫杉醇135mg/m2第1天,顺铂(DDP)30mg/m2第2天~4天,28天为1周期,共用2周期。结果:放化疗组和单纯放疗组近期完全缓解率(CR)分别为90.0%、66.7%(P<0.05),两组5年局部控制率分别为78.3%、55.6%(P<0.05);5年生存率分别为64.1%、50.6%,放化疗组高于单纯放疗组,但P>0.05。放化疗组骨髓抑制和胃肠道反应较单纯放疗组明显(P<0.05),晚期放射性直肠炎和放射性膀胱炎两组无明显差异(P>0.05)。结论:紫杉醇加顺铂化疗同步放疗能提高局部晚期宫颈癌近期疗效和局部控制率,毒副反应患者能耐受。Objective： To evaluate the efficacy and toxicity of combination therapy of chemotherapy with paclitaxel plus cisplatin and concurrent radiotherapy for locally advanced cervical cancer.Methods： 60 cases with cervical cancer stage Ⅱb-Ⅲb were divided into 2 groups randomly.30 cases were in the sole radiotherapy group（group Ⅰ）,30cases were in the chemotherapy plus radiotherapy group（group T）.The method of radiotherapy in group Ⅰ was as same as that in group T.The total radiotherapy dose was 56Gy-60Gy/28f-30f and 18Gy/3f at point A.Chemotherapy method was paclitaxel 135mg/m^2 d1,cisplatin 30mg/m^2 d2-4,for two cycles.Results： In group Ⅰ and group T,the complete regression rates were 66.7% and 90% respectively.The overall 5-year local control rates and 5-year survival rates in the two groups were 55.6% and 78.3%,50.6% and 64.1% respectively.The main toxicities were bone marrow inhibition and reaction of digestive tract in group T.Conclusion： Paclitaxel-based chemotherapy combined with concurrent radiotherapy for stage Ⅱb-Ⅲb cervical cancer can improve the local control rate and the initial response rate with tolerable toxicities.

关 键 词：宫颈肿瘤 紫杉醇 放射治疗 化学治疗 

分 类 号：R737.33[医药卫生—肿瘤] R730.58[医药卫生—临床医学]