1378例角膜移植供体四种监控指标的总结分析  

Detection of four kinds of pathogens in l378 cornea donors

作　　者：黄强 许丽英[1] 王琪[1] 马璇[1] 张艳丽[1] 吴开力[1] 

机构地区：[1]中山大学中山眼科中心,眼科学重点实验室,广州510060

出　　处：《中国实用眼科杂志》2007年第11期1171-1173,共3页Chinese Journal of Practical Ophthalmology

基　　金：国家自然科学基金（30572002）资助

摘　　要：目的初步探讨角膜移植供体的血液监测的安全指标。方法使用ELASA和胶体金法检测1378份角膜供体的血清中HBsAg、抗-HCV、抗-HIV和梅毒抗体。结果在272份阳性血样中,共发现6份HIV初筛阳性、64份抗-HCV阳性、193份HBsAg阳性和39份梅毒抗体阳性;除244份为单一感染外,其它为2～3种病原体混和感染。结论角膜移植供体应进行HIV、HCV、HBV及梅毒检测,以预防这些疾病,特别是艾滋病的传播,保证受体安全,Purpose To investigate the distribution patterns of four kinds of pathogens in cornea donors and the value of the applied measuring methods.Methods One thousand and three hundred seventy eight sera of cornea donor were used to detect the HbsAg,anti-HCV,anti-HIV and anti-Treponema Pallidum （anti-TP）by ELISA（for four pathogens）and colloidal gold immunochromatographic assay（only for anti-TP）. Results Two hundred and seventy two out of 1378 serum samples showed positive immuno-reaction with the assayed markers of four pathogens.Of them,6 were positive against HIV,64 positive against HCV,193 positive against HbsAg and 39 positive against TP.There were 244 sera infected with only one pathogen and 28 sera were infected with two to three pathogens.Conclusion There are high of HIV,HCV,HBV and TP in cornea donor.The measurement of these four pathogens should be applied in clinical practice.

关 键 词：角膜移植 供体 血液检测 ELISA 

分 类 号：R733.7[医药卫生—肿瘤]