Quantification of Erdosteine in the Low-volume of Dog Plasma by Liquid Chromatography Tandem Mass Spectrometry  

作　　者：LIU Dan WANG Yan TANG Yun-biao CHEN Xiao-yan ZHONG Da-fang 

机构地区：[1]Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China [2]The First Hospital of Jilin University, Changchun 130021, P. R. China [3]Department of Pharmacy, General Hospital of Shenyang Military Region, Shenyang 110015, P. R. China

出　　处：《Chemical Research in Chinese Universities》2007年第6期736-741,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Nature Science Foundation of China(No.39930180).

摘　　要：Introduction Erdosteine [ N-（ carboxymethylthioacetyl ）-homocysteine thiolactone ] （ Fig. 1 ） is a synthetic derivative of natural amino acid methionine. It has been commonly used in clinical practice as a mucolytic drug and as an enhancer of respiratory ventilation in the treatment of patients with chronic obstructive respiratory disease. Erdosteine contains 2 blocked sulfhydryl groups, which are released after metabolic transformation in the liver. The liberated sulfhydryl groups break the disulphide bonds, which hold the glycoprotein fibres of mucus together; this makes the bronchial secretions more fluid and allows more rapid elimination. The reducing potential of these sulfhydryl groups accounts for the free radical scavenging and antioxidant properties of erdosteine.Introduction Erdosteine [ N-（ carboxymethylthioacetyl ）-homocysteine thiolactone ] （ Fig. 1 ） is a synthetic derivative of natural amino acid methionine. It has been commonly used in clinical practice as a mucolytic drug and as an enhancer of respiratory ventilation in the treatment of patients with chronic obstructive respiratory disease. Erdosteine contains 2 blocked sulfhydryl groups, which are released after metabolic transformation in the liver. The liberated sulfhydryl groups break the disulphide bonds, which hold the glycoprotein fibres of mucus together; this makes the bronchial secretions more fluid and allows more rapid elimination. The reducing potential of these sulfhydryl groups accounts for the free radical scavenging and antioxidant properties of erdosteine.

关 键 词：ERDOSTEINE Dog plasma PHARMACOKINETICS HPLC/MS/MS 

分 类 号：O657.63[理学—分析化学]