乳腺癌组织CD15与PCNA表达及其临床意义的研究  

Expression and clinical significance of CD15 and PCNA in breast cancer

作　　者：孙丽萍[1] 牛虎[1] 李海[1] 樊伟[1] 李彤[1] 

机构地区：[1]济南市第四人民医院两腺外科,山东济南250031

出　　处：《中华肿瘤防治杂志》2007年第23期1786-1788,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:通过检测CD15抗原及PC-NA在乳腺癌及乳腺增生症中的表达,探讨CD15抗原及增殖细胞核抗原(PCNA)在乳腺癌鉴别诊断中的价值。方法:采用免疫组织化学SP法检测CD15抗原和PCNA在51例乳腺癌及67例乳腺增生症组织中的表达。结果:CD15抗原在51例乳腺癌组织及67例乳腺增生组织中的阳性表达率分别为78.4%(40/51)和44.8%(30/67),PCNA的阳性表达率分别为88.2%(45/51)和68.7%(46/67),这2个指标表达在乳腺癌与乳腺增生之间差异有统计学意义(P=0.000;P=0.012)。CD15抗原及PCNA阳性表达率与乳腺癌患者腋淋巴结状况及组织学分级有显著相关性(P=0.000),而与患者绝经状况(P=0.554;P=0.288)及TNM分期(P=0.081;P=0.055)无显著相关性。在乳腺癌组织中CD15表达与PCNA表达呈正相关(r=0.479,P=0.000)。结论:CD15抗原和PCNA表达与乳腺癌的发生发展有关。联合检测CD15抗原和PCNA可能对乳腺癌的鉴别诊断及早期诊断具有重要参考价值。CD15抗原和PCNA对判断乳腺癌的恶性程度、预测生物学行为和预后有参考价值。OBJECTIVE：To evaluate the value of CD15 antigen and PCNA in differential diagnosis and early diagnosis of breast cancer by determining the level of CD15 and PCNA expre sion in breast cancer and breast hyperplasia. METHODS： The expression of CD15 antigen in 51 cases of breast cancer and 67 cases of breast hyperplasia were investigated by SP immunohistochemical technique. RESULTS： The positive expressive rates of CD15 anti gen in 51 cases of breast cancer and 67 cases of breast hyperplasia were 78.4% （40/51） and 44, 8% （30/67） respectively. The positive expressive rates of PCNA were 88.2% （45/51） and 68.7% （46/67） respectively. The difference was significant（P=0.000; P=0. 12）. The positive expressive rates of CD15 antigen and PC NA in patients of breast cancer were significantly correlated with axillary lymph node status and histological grading （P = 0. 000）, while no significant correlation with patients menopause status （P=0.554; P=0.288） and TNM staging （P=0.081; P=0. 055）. Moreover, there was a positive correlation between CD15 and PCNA expressions in breast cancer, r= 0. 479, P = 0. 000. CONCLUSIONS： The expression of CD15 antigen and PCNA may be related to the carcinogenesis and progression of breast cancer. Combining detection of CD15 antigen and PCNA is useful in differential diagnosis and early diagnosis of breast cancer. The expression of CD15 antigen and PCNA may be useful indicators to evaluate the malignancy and biological features, and can be considered as good prognostic predictors for breast cancer.

关 键 词：乳腺肿瘤 抗原 CD15 增殖细胞核抗原 乳腺疾病 

分 类 号：R737.9[医药卫生—肿瘤]