胃和结直肠肿瘤脉管浸润特点及其临床意义的研究  

Study of vessel invasion in gastrointestinal cancer and its clinical significance

作　　者：高彦[1] 仲伟霞[1] 穆殿斌[1] 孙兰萍[1] 原银萍[1] 蔡淑萍[1] 王磊[2] 于金明[3] 周庚寅[4] 

机构地区：[1]山东省肿瘤防治研究院病理科,山东济南250117 [2]山东省肿瘤防治研究院外科,山东济南250117 [3]山东省肿瘤防治研究院放疗科,山东济南250117 [4]山东大学医学院病理学与病理生理学教研室,山东济南250012

出　　处：《中华肿瘤防治杂志》2007年第23期1795-1797,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:研究胃和结直肠肿瘤血管浸润(BVI)和淋巴管浸润(LVI)的检测方法及其临床意义。方法:应用免疫组化法检测95例胃和结直肠肿瘤组织中CD34和D2-40的表达,根据HE染色和免疫组化染色结果判断BVI和LVI,并分析其临床意义。结果:淋巴管浸润与血管浸润显著相关,P<0.001。免疫组化法发现的脉管浸润显著高于HE法发现的脉管浸润,P<0.001。肿瘤浸润深度与BVI(1.5%vs33.3%,P<0.001)和LVI(7.7%vs40.0%,P<0.001)显著相关。淋巴结转移状态与BVI(6.9%vs26.1%,P=0.022)和LVI(6.9%vs52.2%,P<0.001)显著相关。结论:免疫组化法比常规HE法有更高的特异性和敏感性;BVI和LVI可能是胃癌和结直肠癌重要的预测预后因子。OBJECTIVE： To explore the method of detecting blood vessel invasion （BVI） and lymphatic vessel invasion （LVI） and the significance of BVI and LVI. METHODS： Expression of CD34 and D2-40 of 95 patients with gastrointestinal cancer were detected by immunohistochemistry （IHC）. BVI and LVI were detected by IHC and HE staining. RESULTS： BVI was correlated with LVI significantly, P〈0.001. IHC staining detected more vessel invasion than HE staining did, P〈0. 001. The depth of invasion of tumor was correlated significantly with BVI （ 1.5 % vs 33.3%, P〈0.001） and LVI （7.7% vs 40.0%, P〈0.001）. The statues of lymph nodes was correlated significantly with BVI （6.9% vs 26.1%, P=0.022）and LVI （6.9% vs 52.2%, P〈 0. 001）. CONCLUSIONS： The sensitivity and specificity of IHC staining was higher than those of HE staining in detecting vessel invasion. BVI and LVI seem to be prognostic factors to gastrointestinal cancers.

关 键 词：胃肿瘤 结肠直肠肿瘤 肿瘤浸润 

分 类 号：R735[医药卫生—肿瘤]