非小细胞肺癌组织中FHIT和HER2的表达及其临床意义的研究  

Expressions and clinical significance of FHIT and HER2 proteins in non-small cell lung cancer

作　　者：江拥军[1] 尹邦良[1] 

机构地区：[1]中南大学湘雅二院胸心外科,湖南长沙410011

出　　处：《中华肿瘤防治杂志》2007年第24期1875-1878,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨FHIT和HER2在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达,及两者的联合表达对判断NSCLC预后和转归的价值。方法:SP法检测90例NSCLC标本中FHIT和HER2的表达。结果:NSCLC组织中FHIT蛋白失表达率53.75%(43/80)显著低于肺良性病变组织的10%(1/10),其失表达率与吸烟(P=0.000)、组织学类型(P=0.004)、淋巴结转移(P=0.002)、pTNM分期(P=0.028)及3年无瘤生存率(P=0.047)存在相关性。HER2蛋白的过表达率62.50%(50/80)却显著高于肺良性病变组织的0(0/10),其过表达率则与淋巴结转移与否(P=0.030)、pTNM分期(P=0.018)及3年无瘤生存率(P=0.028)存在相关性。FHIT蛋白的失表达与HER2蛋白过度表达呈显著负相关,P<0.05。结论:FHIT基因蛋白的失表达和HER2基因蛋白的过表达可能在NSCLC发生和发展过程中起重要作用,并影响预后。OBJECTIVE：To investigate the expressions and clinical significance of FHIT and HER2 proteins in non-small cell lung carcinoma and their correlations. METHODS： The expressions of FHIT and HER2 proteins were detected by SP immunohistochemical technique among pathology specimen （90 cases）. RESULTS： The deletion rate of FHIT protein expression in NSCLC tissues [53. 75% （43/80）] was lower than that in benign pulmonary lesion tissues [10% （1/10）] significantly, while the over-expression of HER2 protein in NSCLC tissues [62. 5%（50/80）] was higher than that in benign pulmonary lesion tissues [0 （0/10）] significantly, P 〈 0.01. The deletion rate of FHIT protein expression was related to smoking （P=0. 000）, cancer cell differentiation （P = 0. 004）, lymph node metastasize （P=0. 002）, pTNM stages （P=0. 028） and the rate of cases without recurrence in 3 years （P=0. 047） in NSCLC patients. The over-expression of HER2 protein was related to lymph node metastasize or not （P=0. 030）, pTNM stages （P=0. 018） and the rate of cases without recurrence in 3 years （P=0. 028） in NSCLC patients. The deletion rate of FHIT protein expression and the over-expression of HER2 protein were negative correlated significantly, P〈0.05. CONCLUSION： The deletion rates of FHIT protein expression and the over-expression of HER2 protein may play important roles in the tumorigenesis and the prognosis of NSCLC.

关 键 词：癌 非小细胞肺 FHIT HER2 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]