消化道肿瘤组蛋白乙酰化与甲基化的研究进展  

Development in research on histone acetylation and methylation in alimentary canal neoplasms

作　　者：彭过[1] 戴冬秋[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤外科,辽宁沈阳110001

出　　处：《中华肿瘤防治杂志》2007年第24期1914-1917,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：组蛋白乙酰化、甲基化及磷酸化等共价修饰以及染色质的其他改变如DNA甲基化和ATP依赖的染色质重组在肿瘤形成的多阶段过程中发挥重要作用。消化道肿瘤是我国的常见肿瘤。主要探讨组蛋白共价修饰中乙酰化和甲基化在消化道肿瘤形成过程中的作用。对了解消化道肿瘤的发病机制、细胞免疫与防御、细胞分化以及预防治疗等方面具有十分重要的意义。Covalent modifications of histones, such as acetyla tion, methylation and phosphorylation, and other epigenetic modulations of the chromatin including methylation of DNA and ATP dependent chromatin reorganisation, can play a major part in the mul tistep process of carcinogenesis. Alimentary canal neoplasm is the most common cancer. This review focuses on how aberrant covalent histone modifications such as acetylation and methylation may con tribute to the development of alimentary canal neoplasms. The investigation has most sense about cell immunity, phylaxis, cell differ-entiation and preventive therapy.

关 键 词：消化道肿瘤 表遗传学 组蛋白乙酰化 组蛋白甲基化 综述文献 

分 类 号：R735[医药卫生—肿瘤]