壳寡糖协同双歧杆菌对荷瘤鼠免疫功能的影响  

Effects of Chitosan Oligosaccharide and Bifidobacteria on Immune Function in Tumor-bearing Mice

作　　者：官杰[1] 吴艳敏[1] 王慧[1] 钱丽丽[1] 李殿俊[1] 

机构地区：[1]齐齐哈尔医学院免疫教研室,齐齐哈尔161042

出　　处：《癌变．畸变．突变》2007年第6期487-490,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：黑龙江省教育厅科学技术研究面上项目(11511457)

摘　　要：背景与目的:建立H22肝癌荷瘤鼠实验动物模型,研究壳寡糖协同双歧杆菌对荷瘤鼠免疫功能的影响。材料与方法:采用体内注射的方法将壳寡糖和双歧杆菌注入荷瘤小鼠体内,观察肿瘤生长情况,并进行免疫功能的测定,及观察肿瘤病理变化。结果:壳寡糖协同双歧杆菌对肿瘤的生长有抑制作用,可提高荷瘤小鼠血清的IL-2和INF-γ含量,增加荷瘤小鼠免疫器官脾脏和胸腺的重量,显微镜下观察显示肿瘤组织出现坏死。结论:壳寡糖协同双歧杆菌可抑制肿瘤生长,提高机体免疫功能,促使肿瘤细胞坏死。BACKGROUND ＆ AIM： Establish the tumor animal model of the H22 liver cancer in mice,and study the inhibition effects of chitosan oligosaccharide and bifidobacteria on the tumor. MATERIALS AND METHODS： Chitosan oligosaccharide and bifidobacteria were injected into tumor-bearing mice,the growth and pathological changes of the tumor were examined; and the immunological functions were measured. RESULTS： Growth of tumor were inhibited by chitosan oligosaccharide and bifidobacteria. They could increase the content of IL-2 and IFN-7 and the weights of spleen and thymus of the mice.Necrosis was observed in the tumor tissue. CONCLUSION： Chitosan oligosaccharide and bifidobacteria could inhibit the growth of tumor, improve immunity and induce tumor necrosis.

关 键 词：壳寡糖 双歧杆菌 肿瘤 抑制 

分 类 号：R73-36[医药卫生—肿瘤] R392.12[医药卫生—临床医学]