利培酮治疗青少年精神分裂症疗效观察  

Therapeutic effect of risperidone on childhood schizophrenia

作　　者：钱建军[1] 徐红英[1] 严伟亮[1] 董莹盈 高赛男[1] 

机构地区：[1]浙江省绍兴市第七人民医院心理科,绍兴312000

出　　处：《实用药物与临床》2007年第6期340-342,共3页Practical Pharmacy and Clinical Remedies

基　　金：绍兴市科技局基金资助项目(2005193)

摘　　要：目的探讨利培酮治疗儿童精神分裂症疗效及不良反应。方法对86例首发儿童精神分裂症患儿给予利培酮治疗8周,分别以PANSS量表和TESS量表评定疗效及不良反应。结果利培酮治疗儿童精神分裂症显效率为74.42%,阳性症状起效时间为2周左右,阴性症状起效时间为4周。治疗剂量0.75-7 mg/d,平均（2.63±1.88）mg/d。结论利培酮对儿童精神分裂症阳性、阴性症状均有效,不良反应较少,但要注意个体化用药原则。Objective To explore the effects and adverse effects of risperidone on childhood schizophrenia. Methods Eighty-slx first episode childhood schizophrenics patients were treated with risperidone for 8 weeks, the efficacy and adverse effects were examined by positive and negative symptom scale （PANSS） and treatment emergent symptom scale （TESS）. Results The effective rate of risperidone was 74.42 %, the onset time of positive and negative symptoms were approximately 2 and 4 weeks respectively. The treating dose is 0.75--7 mg/d, and （2.63 ± 1.88） mg/d in average. Conclusion Risperldone is effective on positive and negative symptoms of childhood schizophrenia, and it has less adverse effect, however, doctors should pay close attention to individual dosing policies.

关 键 词：利培酮 儿童精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]