载脂蛋白E基因多态性与Alzheimer病的关联研究  

A correlated study of apoE gene polymorphism and Alzheimer disease

作　　者：麦以成 罗有年 顾鸿 幺宪伟 付燕[2] 郑洪波[2] 胡文生[2] 黎艳[3] 吴仲扬 林静静 

机构地区：[1]广东佛山市顺德区伍仲珮纪念医院,528300 [2]广州市脑科医院 [3]广东佛山市第三人民医院 [4]广东佛山市顺德区颐养院

出　　处：《临床精神医学杂志》2007年第6期365-366,共2页Journal of Clinical Psychiatry

基　　金：广东省佛山市医学科学技术研究基金资助项目(编号:2005491)

摘　　要：目的:观察载脂蛋白E(apolipoprotein E,apoE)基因多态性在广东佛山地区汉族老年人中的分布,探讨其与晚发Alzheimer病(AD)的相关性。方法:对88例晚发AD患者和97名正常老年人进行对照研究。用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)分析apoE基因多态性。结果:晚发AD患者中apoE等位基因ε4频率为18.8%,较正常老年人组显著升高,并与晚发AD呈正关联(OR=2.27,χ2=8.859,P<0.01)。结论:apoE等位基因ε4是晚发AD主要的遗传风险因子。Objective：To investigate the distribution of apolipoprotein E （apoE） gene polymorphism in Chinese Han senior citizens in Guangdong Foshan area and explore its relationship with later-onset Alzheimer disease （AD）. Method：Case-control study was conducted in 88 patients with later-onset AD and 97 normal senior citizens. Their apoE gene polymorphism were analyzed with polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP）. Results： The frequency of apoE ε4 allele in patients with later-onset AD （18.8 % ） was higher than that in normal senior citizens and positively correlated with later-onset AD （ OR = 2.27, Х^2 = 8. 859, P 〈 0.01 ）. Conclusion： apoE ε4 allele is an important genetic factor for later-onset AD.

关 键 词：载脂蛋白E ALZHEIMER病 基因多态性 

分 类 号：R749.1[医药卫生—神经病学与精神病学]