P53蛋白高表达与林县食管癌关系的病例对照研究  

A case control study on relationship between overexpression of P53 protein and esophageal carcinoma in Linxian

作　　者：张秀玲[1,2,3] 李良寿[1,2,3] 徐德忠 孙长生[1,2,3] 杨文献 赵恒忠[1,2,3] 常贵生 阎明晓[1,2,3] 王嫣 

机构地区：[1]第四军医大学流行病学教研室 [2]河南省肿瘤研究所 [3]林州市肿瘤医院

出　　处：《第四军医大学学报》1997年第4期330-332,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：探讨Ｐ５３蛋白高表达在食管癌发病中的意义．方法：于１９９５年１０月～１２月在林县进行了病例对照调查，并收集了组织学材料．采用免疫组化ＳＰ法，对病例组（５９例）手术切除的癌组织和对照组（３７例）食管粘膜活检标本的Ｐ５３蛋白表达情况进行了检测．结果：５７．６％（３４／５９）的病例标本和１６．２％（６／３７）的对照标本存在有Ｐ５３蛋白高表达，病例组明显高于对照组（Ｐ＜０．０１）．单因素分析有显著意义的因素为Ｐ５３蛋白高表达、病前２０年食酸菜史、病前１０年食水果史和食管癌家族史，其比值比（ＯＲ）及其９５％可信限（ＣＩ）分别为７．０３（２．３３～２２．２１）、２．９８（１．１０～８．２０）、０．１９（０．０４～０．９０）和２．５１（０．９９～６．４４，Ｐ＜０．０５）．男性、女性Ｐ５３蛋白高表达的ＯＲ（９５％ＣＩ）及合并ＯＲ（９５％ＣＩ）分别为７．３８（１．９６～２９．６４）、８．１７（０．７７～２０３．３６）和７．５８（２．４１～２５．０１），与分层前ＯＲ接近．多因素Ｌｏｇｉｓｔｉｃ回归分析显示Ｐ５３蛋白高表达的ＯＲ（９５％ＣＩ）为５．９１（１．９５～１８．２７）．结论：结果提示Ｐ５３蛋白高表达与食管癌之间存在?Objective: To evaluate the strength of association between overexpression of P53 protein and esophageal carcinoma, a case control study was carried out in Linxian, Henan province, northern China. Methods: From October to December 1995, epidemiological data and tissue specimens were collected. Overexpression of P53 protein was detected by immunohistochemistry in carcinoma specimens from surgically resected human esophagi in case group (59 cases) and in tissue specimens of esophagus by endoscopic biopsy in control group (37 controls). Results: Overexpression of P53 protein was present in 57.6% (34/59) of case group and in 16.2% (6/37) of control group. The difference between groups was significant ( P <0.01). Odds Ratio (95% CI) of overexpression of P53 protein was 7.03 (2.33～22.21). For other significant factors such as pickled vegetables, fruits and family history by univariate analysis, Odds Ratio (95% CI) was 2.98 (1.10～8.20), 0.19 (0.04～0.90) and 2.51 (0.99～6.44; P <0.05), respectively. Odds Ratio of overexpression of P53 protein was 7.38 (1.96～29.64) for male and 8.17 (0.77～203.6) for female by sex stratification analysis. Sumed OR was 7.58 (2.41～25.01). The results calculated by multiple logistic regression analysis showed that Odds Ratio of overexpression of P53 protein was 5.91 (1.95～18.27). Conclusion: These findings indicate that overexpression of P53 protein is strongly associated with esophageal carcinoma, which might play an important role in the development of esophageal carcinoma.

关 键 词：食管肿瘤 P53蛋白 流行病学 

分 类 号：R735.101[医药卫生—肿瘤]