局部晚期乳腺癌术前动脉灌注化疗的临床疗效及病理分析  

Long term results of preoperative chemotherapy for operable breast cancer

作　　者：蔡玉娥[1] 张斌[1] 庞秀梅[1] 王彦[1] 罗亚红[1] 

机构地区：[1]辽宁省肿瘤医院乳腺科

出　　处：《中华肿瘤杂志》1997年第4期277-280,共4页Chinese Journal of Oncology

摘　　要：局部晚期乳腺癌术前动脉灌注化疗的临床疗效及病理分析蔡玉娥张斌庞秀梅王彦罗亚红局部晚期乳腺癌术前动脉灌注化疗国内、外研究尚少，现对２３例局部晚期乳腺癌术前动脉灌注化疗的临床疗效和病理组织学总结分析如下。资料与方法２３例女性原发性局部晚期乳腺癌，年龄３０...Objective To evaluate the long term therapeutic results of preoperative chemotherapy for operable breast cancer. Methods Patients were divided into preoperative chemotherapy group(group A, 253 cases) and postoperative adjuvant chemotherapy group(group B, 284 cases). The group A patients received preoperative chemotherapy for 4 weeks, followed by radical operation two weeks after chemotherapy. Postoperative adjuvant chemotherapy began within 2 weeks after surgery, with the same chemotherapeutic regimen for 6 or more cycles in both groups. Results (1) The 5 year overall survival rate (OS) and disease free survival rate(DFS) were 59% and 54.9%, respectively, for group A in stage Ⅲ, which were higher than those of group B(28.3% and 20.8%, P <0.05). (2) For group A in stage Ⅱ and Ⅲ, the 8 year OS were 81.4% and 46.9%, and DFS were 76.3% and 40.6%, respectively, which were higher than those of group B(OS: 67.4% and 20.7%, DFS: 62.9% and 13.3%, P <0.05). (3) The 5 year and 8 year OS were higher for group A than those for group B in patients with T 3, T 4 or positive nodes≥4,( P <0.05). Conclusion The results show that preoperative chemotherapy can improve the short and long term survival of patients with operable, stage Ⅲ breast cancer and long term survival of patients with stage Ⅱ breast cancer.

关 键 词：乳腺肿瘤 放射疗法 外科手术 存活率 

分 类 号：R737.905[医药卫生—肿瘤]