非霍奇金淋巴瘤患者血清肿瘤坏死因子α的水平与预后  

Serum tumor necrosis factor alpha levels in non Hodgkin`s lymphoma patients and its relationship to prognosis

作　　者：李大启[1,2] 李公宝[1,2] 王宝珍[1,2] 杨金平[1,2] 胡美玉[1,2] 

机构地区：[1]山东潍坊医学院附属医院 [2]上海医科大学附属中山医院血液科

出　　处：《中华肿瘤杂志》1997年第4期293-296,共4页Chinese Journal of Oncology

摘　　要：目的探讨肿瘤坏死因子α（ＴＮＦα）与非霍奇金淋巴瘤（ＮＨＬ）的关系，评价血清ＴＮＦα测定的临床价值。方法采用双抗体夹心酶联免疫吸附试验（ＥＬＩＳＡ），检测７６例ＮＨＬ患者血清ＴＮＦα水平，并进行动态观察和患者生存状况分析。结果５５％的初诊ＮＨＬ患者血清ＴＮＦα水平升高，化疗缓解后降至正常，复发时再次升高。血清ＴＮＦα水平与患者的ＡｎｎＡｒｂｏｒ分期、肿块大小、Ｂ症状有关，与血清乳酸脱氢酶、β２微球蛋白无关。血清ＴＮＦα升高患者的生存期显著低于未升高者。结论血清ＴＮＦα的水平与患者的高肿瘤负荷有关，可作为判断预后的一项指标。Objective To explore the relationship of tumor necrosis factor alpha (TNFα) with non Hodgkin`s lymphoma (NHL) and to evaluate clinical implication of serum TNFα. Methods Serum TNFα levals were measured by double antibody sandwich enzyme linked immunosorbent assay (ELISA) in 76 NHL patients. Survival analysis was performed. Results Serum TNFα was increased in 55% newly diagnosed patients, and dropped to normal level on remission but increased again on relapse. Elevated TNFα levels of patients at diagnosis were significantly associated with Ann Arbor stage, bulky tumor and B symptoms, but weren`t correlated to serum lactic dehydrogenase (LDH) nor to β 2 microglobulin (β 2 MG). The survival period of patients with elevated TNFα levels was shorter than that of patients with normal TNFα levels.Conclusion Elevated serum TNFα level is associated with high tumor burden and can be used as a prognostic marker.

关 键 词：非霍奇金 淋巴瘤 肿瘤坏死因子 预后 

分 类 号：R733.407[医药卫生—肿瘤]