非酒精性脂肪肝与胰岛素抵抗关系的观察  

Association of Insulin Resistance with Nonalcoholic Fatty Liver Disease

作　　者：陈小桃[1] 黄锦华[1] 

机构地区：[1]广东省佛山市高明区人民医院内二科,广东佛山528500

出　　处：《河北医学》2007年第4期479-481,共3页Hebei Medicine

摘　　要：目的:探讨非酒精性脂肪肝(NAFLD)发病与患者空腹血糖(FBG)、胰岛素抵抗指数(IR)、体重指数(BM I)及血脂紊乱的关系。方法:56例NAFLD患者,年龄、性别相匹配的正常对照者56例,检测空腹血糖、空腹胰岛素水平及血脂,采用稳态模式评估法计算胰岛素抵抗指数,测量身高、体重,计算BM I及腰臀比。结果:NAFLD组与对照组之间空腹胰岛素、胰岛素抵抗指数、BM I及血脂紊乱比较有显著差异(P<0.05或0.01);多元逐步回归显示,胰岛素抵抗、腰臀比是影响肝脏脂肪含量主要的危险因素。结论:胰岛素抵抗、腰臀比是影响NAFLD的主要危险因素。Objective： To investigate the relationship among homeostasis model assessment of insulin re- sistance （ HOMA - IR） , blood glucose, body mass index（BMI） , waist - to - hip ratio（WHR） and dyslipi- dema in patients with non alcoholic fatty liver disease （ NAFLD ）. Methods： 56 NAFLD patients and 56 matched normal control groups, the level of homeostasis model assessment of HOMA -IR, blood glucose, WHR were measured. Results： HOMA - IR index, BMI, WHR and dyslipidema showed significant differ-ence between NAFLD, and normal groups （ P 〈 0.05 or P 〈 0.01 ）. Multiple stepwise regression analysis showed that HOMA - IR and WHR were the independent risk factors affecting. Conclusion： HOMA - IR and WHR can be important risk factors of NAFLD.

关 键 词：非酒精性脂肪肝 胰岛素抵抗指数 临床观察 

分 类 号：R575.5[医药卫生—消化系统]