胰腺癌血管形成与其病理特征及预后的关系  

The correlation between tumor angionenesis and pathological characteristics and prognosis in pancreatic carcinooma

作　　者：吕强声[1] 王亚东[1] 高远东[1] 程田海[1] 

机构地区：[1]滨海县人民医院,江苏滨海224500

出　　处：《基层医学论坛（B版）》2007年第12期1057-1058,共2页Public Medical Forum Magazine

摘　　要：目的探讨胰腺癌组织中微血管生成与其病理特征及预后的关系。方法应用免疫组化S-P法以CD34单克隆抗体特异性标记胰腺癌组织血管内皮细胞及正常胰腺组织血管内皮细胞,检测其微血管密度(MVD)并与临床病理特征及预后对比分析。结果胰腺癌组织中微血管密度明显高于正常胰腺组织(51.3±21.5、26.6±9.2,P<0.01)。MVD与肿瘤大小及病理类型无关,而淋巴结转移(P<0.01)、肿瘤细胞分化程度(P<0.05)、临床分期(P<0.01)和预后明显相关。结论胰腺癌组织中微血管密度高于正常胰腺组织,其微血管生成与病理特征及预后有密切关系。Objective To study the relationship between tumor micro-angiogenesis and pathological characteristics and prognosis in pancreatic carcinoma （PCA）.Methods S-P immunohistoehemieal method and CD34 antibody was used to detect the micro-vascular density （MVD） in pancreatic carcinoma and normal pancreatic tissue.Results MVD in PCA was 51,3 ～ 21.5, while MVD in normal pancreas tissue was 26.6 ～ 9.2.MVD in PCA of low differentiation was higher than that in PCA of high differentiation. MVD in PCA with lymph node metastasis was higher than that in PCA without lymph node metastasis. Patients with low MVD may have good prognosis. Conclusion MVD is higher in pancreatic carcinoma than that in normal pancreatic tissue, MVD is closely related to pathological characteristics and prognosis in pancreatic carcinoma.

关 键 词：胰腺肿瘤 微血管密度 预后 

分 类 号：R735.2[医药卫生—肿瘤]