胰岛素受体底物3、4、p53在正常大鼠大脑中的分布  

Distribution of IRS-3,IRS-4 and IRS-p53 in the brain of normal adult rat

作　　者：陆珊[1] 雷亚平[1] 王蓬文[1] 盛树力[2] 田金洲[1] 

机构地区：[1]北京中医药大学东直门医院,北京中关村医院100700 [2]教育部神经变性病学重点实验室

出　　处：《中国糖尿病杂志》2007年第11期690-692,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金资助项目(NO30672693);北京市自然科学基金重点资助项目(7071005)

摘　　要：目的观察胰岛素受体底物(IRS)3、4、p53在正常大鼠大脑中的分布。方法应用免疫组织化学方法研究了IRS-3、IRS-4、IRS-p53在正常成年大鼠脑内的分布和定位。结果IRS-3、IRS-4、IRS-p53在正常成年大鼠脑中分布广泛,在脑内与学习记忆相关的各主要结构如大脑皮质、海马、丘脑和下丘脑的部分核团均有表达。结论IRS-3、IRS-4、IRS-p53在正常成年大鼠脑中有很广泛的表达,提示这几种底物在维持大鼠大脑的正常功能中可能起重要作用。Objective To study the distribution of IRS-3,4,p53 in the brain tissues of normal adult rats. Methods The distributions of IRS-3,4, p53 in the brain tissues of normal rats were detected by immunohistochemical staining. Results In the brain of normal rats,the positive IRS-3,4,p53-stained neurons were widely distributed in several regions ,such as cortex, hippocampus and thalamus et al,which were correlated with study and memory capabilities. Conclusion IRS-3,4,p53 are widely distributed in the brain tissues of normal adult rats, which suggests these substrates may be important to maintain the normal function of brains.

关 键 词：胰岛素受体底物 中枢神经系统 染色法 免疫组织化学 

分 类 号：R741[医药卫生—神经病学与精神病学]