β-catenin、MMP-7蛋白在不同级别胶质瘤组织中的表达及临床意义  

Expression of β-catenin and MMP7 in Various Grade of Glioma and its Clinical Significance

作　　者：潘旭波[1] 纪祥瑞[2] 姜蕾[1] 王威[1] 徐振光[1] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院病理科,264000 [2]青岛大学医学院病理科

出　　处：《实用癌症杂志》2007年第2期164-166,共3页The Practical Journal of Cancer

摘　　要：目的探讨不同级别胶质瘤组织中β-catenin、MMP-7的表达及其临床意义。方法制作89例胶质瘤及6例正常脑组织的组织芯片,采用免疫组化二步法,检测芯片中β-catenin、MMP-7在正常脑组织和胶质瘤中的表达。结果正常脑组织中β-catenin、MMP-7表达均为阴性(-);在不同级别胶质瘤中β-catenin、MMP-7均有表达,并随肿瘤级别增高而增高,差别有统计学意义(P分别=0.01,<0.05);相关分析发现β-catenin表达与MMP-7的表达相关(P=0.01)。结论提示β-catenin在细胞质、核内的集聚可促进MMP-7的表达,与胶质瘤的发生、发展、侵袭性有关,可反映胶质瘤的恶性程度和病理分级。Objective To investigate the expression of β-catenin and MMP7 in various grade of glioma and the clinical significance. Methods Tissue microarray were constructed including 89 glioma and 6 normal brain tissues. Two step immunohistochemical staining was used to examine the expression of β-catenin and MMP7 in various grade of ghoma and normal brain tissues. Results Normal brain tissues showed negative expression forβ-catenin and MMP7. A higher expression of β-catenin and MMP7 could be observed with the increasing grade of glioma. The expression of β-catenin and MMP7 were significantly different in low-grade and high-grade glioma （P 〈 0.01 ,P 〈 0.05 respectively ）. The expression of β-catenin had close correlation to that of MMP7 in glioma （ P 〈 0.01 ）. Conclusion The accumulation of β-catenin in cytoplasm and nuclear could promote the expression of MMPT, which might be associated with tumorigenesis, development and aggression of glioma. The expression of β-catenin suggested the malignant degree and grade of glioma.

关 键 词：胶质瘤 组织芯片 Β-连接素 基质金属蛋白酶-7 

分 类 号：R739.4[医药卫生—肿瘤]