3,7-二氟-10,11-二氢-二苯并[b,f]-氮杂▌的合成  

Synthesis of 3,7-difluoro-10,11-dihydro-5H-dibenz[b,f] azepine

作　　者：李雯[1] 周游[2] 章亚东[1] 胡国勤[1] 李华[1] 

机构地区：[1]郑州大学化工学院,河南郑州450001 [2]郑州大学药学院,河南郑州450001

出　　处：《化学试剂》2007年第12期759-760,共2页Chemical Reagents

摘　　要：以4-氟-2-硝基甲苯为原料,经聚合、还原、缩合得到标题化合物,总收率20.3%。该方法步骤少、操作简便、收率较高,具有工业应用价值。3, 7-Difluoro-10, 11-dihydro-5H-dibenz [b, f] azepine was synthesized from 4-fluoro-2-nitro-toluene used as the raw material via condensation, reduction and cyclization. The total yield of target product reached 20.3 %. The method is most suitable for commercialization thanks to its convenient preparation steps, simplicity and high yield.

关 键 词：3 7-二氟-10 11-二氢-二苯并[b f]-氮杂■ 还原 环合 合成 

分 类 号：O625[理学—有机化学]