血管性认知障碍与血管紧张素Ⅰ转换酶基因多态性的临床分析  

Relationships between vascular cognitive impairment and angiotensin 1 converting enzyme gene polymorphism

作　　者：杨凌[1] 魏永祥[1] 赤克美[2] 刘小超[1] 余华峰[2] 

机构地区：[1]首都医科大学附属北京同仁医院中心实验室,100730 [2]首都医科大学附属北京同仁医院神经内科,100730

出　　处：《北京医学》2007年第12期732-735,共4页Beijing Medical Journal

摘　　要：目的探讨血管性认知障碍(VCI)与血管紧张素I转换酶(ACE)基因插入/缺失多态性的相关性,同时观察血清ACE水平与ACE基因多态性及疾病的关系。方法采用PCR方法对44例VCI患者和71例健康体检者进行ACE基因内含子16插入/缺失多态性的检测,并用紫外分光光度法测定血清ACE水平。结果VCI组D等位基因频率0.33,DD基因型频率为0.18,与对照组(0.41,0.22)比较无显著性差异;DD基因型对VCI的比数比为1.06(95%CI为0.26～4.24,P﹥0.05);各组中DD基因型个体血清ACE水平最高,II基因型最低,基因多态性与血清ACE水平呈正相关(r=0.59,P﹤0.01)。结论ACE基因多态性与本组脑梗死伴VCI患者无关,ACE基因插入/缺失多态性不参与本组入选患者的发病。Objective To investigate the association between vascular cognitive impairment （VCI） and the insertion/deletion polymorphism of angiotensin 1 converting enzyme （ACE） gene in Chinese and to explore the interaction of serum ACE levels and ACE gene polymorphism with the development of the associated diseases, Methods ACE genotypes of 44 cases with VCI and 71 controls were determined by polymerase chain reaction （PCR）. Serum ACE levels were measured with ultraviolet photometry. Results The frequencies of D allele （0.33） and DD genotype （0.18） were observed in 44 subjects with VCI compared with 71 control subjects（0.41,0.22,P 〉 0.05）. The odds ratio associated with DD/II geno- type was 1.06（95%CI 0.26-4.24,P 〉 0.05） for VCI. Individuals with DD genotype had the highest serum ACE in all groups, and with the lowest levels of II genotype. There was no difference in allele distribution between 44 VCI patients and the controls. ACE gene polymorphism was associated with serum ACE levels（r=0.59, P 〈 0.01）. Conclusions There is no significanct difference between the polymorphism of the vascular cognitive impairment and ACE gene polymorphism. Therefore ACE gene polymorphism may not be a risk factor for developing vascular cognitive impairment.

关 键 词：血管性认知障碍 血管紧张素转化酶 基因多态性 

分 类 号：R749.1[医药卫生—神经病学与精神病学]