大肠癌患者血清畸胎瘤衍生生长因子1临床检测意义  

Clinical significance of teratocarcinoma-derived growth factor-1 in serum of human colon cancer patients

作　　者：范钰[1] 王崇强[1] 张尤历[1] 吴莺[1] 曹亮[1] 

机构地区：[1]江苏大学附属医院消化科,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2007年第6期488-489,492,共3页Journal of Jiangsu University：Medicine Edition

基　　金：镇江市社会发展基金资助项目(SH2006019)

摘　　要：目的:探讨检测大肠癌患者血清畸胎瘤衍生生长因子1(teratocarcinoma-derived growth factor1,TDGF1)水平的临床意义。方法:应用sandwich-酶联免疫吸附法(ELISA)技术检测39例大肠癌患者和36例健康者血清中TDGF1含量。结果:大肠癌患者血清TDGF1水平明显高于对照组(P<0.0001);大肠癌患者血清TDGF1含量和患者的年龄、性别及组织病理分化程度无关,而与淋巴结转移、肝转移和Duke′s分期密切相关。结论:血清TDGF 1有可能成为一个新的肿瘤标志物而用于评价大肠癌进展的指标。Objective： To explore the clinical significance of serum teratoearcinoma-derived growth fac- tor 1 （TDGF1） in patients with colorectal cancer. Methods： Serum TDGF1 levels of 39 patients with colon cancer were measured by sandwich enzym-linked immunosorbent assay （ELISA）. and 36 normal healthy volunteers served as control. Results： The serum TDGF1 level of patients with colorectal cancer was signifi- cantly higher than that of the control group（P 〈0.0001 ）. The serum TDGF1 level in colorectal cancer patients with lymph node metastasis, liver metastasis and Duke＇s stage were significantly higher than that in colorectal carcinoma patients without lymph node metastasis, liver metastasis, and Duke＇s stage, respectively. Conclusion ： Serum TDGF1 may be used as a new tumor marker of colorectal cancer for diagnosis and evaluating the progress.

关 键 词：大肠肿瘤 畸胎瘤衍生生长因子1 临床意义 

分 类 号：R735.3[医药卫生—肿瘤]