p73基因在鼻咽癌组织中的表达与临床意义  

Expression of p73 gene in nasopharyngeal carcinoma and clinical significance

作　　者：吴建农[1] 刘敏[1] 李清[2] 高峰 潘碧峰[2] 崔大祥[2] 

机构地区：[1]江苏大学附属医院病理科,江苏镇江212001 [2]上海交通大学微纳科学技术研究院,上海200030

出　　处：《江苏大学学报（医学版）》2007年第6期521-522,525,共3页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:探讨p73基因在鼻咽癌组织中的表达及其与临床预后的相关性。方法:采用定量RT-PCR技术检测35例鼻咽癌组织中p73基因的表达程度。结果:定量RT-PCR检出p73基因在26例鼻咽癌组织中呈高表达。在20例中高分化标本中检出13例呈中高表达,在15例低分化标本中检出13例呈中高表达,两者之间差异有统计学意义(P<0.01);p73基因在9例(9/18)Ⅰ-Ⅱ期鼻咽癌标本中呈中高表达,在17例(17/17)Ⅲ-Ⅳ期鼻咽癌标本中呈中高表达。p73基因表达程度在鼻咽癌Ⅰ-Ⅱ期与Ⅲ-Ⅳ期之间的差异有统计学意义(P<0.05)。结论:p73基因mRNA的表达可能与鼻咽癌分化程度有关,与不良预后有关,与临床分期有关。Objective： To investigate the expression of p73 gene in nasopharyngeal carcinoma tissue and its clinical significance. Methods ： The expression of p73 gene in 35 specimens of nasopharyngeal carcinoma was detected by quantitative RT-PCR. Results： Twenty-six specimens of nasopharyngeal carcinoma exhibited overexpression of p73 gene by QRT-PCR, 13 of which were from 20 well and moderately differentiated specimens, 13 cases were from 15 low differentiated specimens; 9 of which were from 18 specimens of Stage I-Ⅱ, 17 of which were from 17 specimens of Stage Ⅲ-Ⅳ, Statistical difference in examination rates of p73 gene existed between nasopharyngeal carcinoma of Stage I-Ⅱ and Stage Ⅲ-Ⅳ（ P 〈0.05 ）. Conclusion： The overexpression of p73 gene may be related to differentiation degree of nasopharyngeal car- cinoma and poor prognosis as well as clinical stage.

关 键 词：鼻咽癌 P73 聚合酶链反应 

分 类 号：R739.62[医药卫生—肿瘤]