L-抗坏血酸-2-磷酸酯镁的合成  

Synthesis of Magnesium L Ascorbate 2 phosphate

作　　者：刘毓林[1] 石明孝[1] 沈海峰 

机构地区：[1]浙江大学化学系

出　　处：《精细化工》1997年第2期19-22,共4页Fine Chemicals

摘　　要：Ｌ抗坏血酸与丙酮反应生成５，６Ｏ异丙叉Ｌ抗坏血酸（ＩＡＡ），再与三氯氧磷进行磷酸化反应，脱保护合成Ｌ抗坏血酸２磷酸酯镁。合成ＩＡＡ，采用氯化亚锡为催化剂，可得９４３％的收率。最佳磷酸化反应介质为一保持ｐＨ１２０～１２５并含高浓度吡啶（初始浓度大于２２ｍｏｌ／Ｌ）的０～１０℃的水溶液。对有关产物的结构作了表征。L Ascorbic acid reacted with acetone to prepare 5,6 O isopropylidene L ascorbic acid(IAA),then phosphorylation with phosphoryl chloride and removing protective group to synthesize magnesium L ascorbate 2 phosphate.Using tin protochloride as catalyst to synthesize IAA,the yield of the product can give 94.3%.The optimum phosphorylation medium was an aqueous solution maintaining pH 12 0～12 5 at 0～10℃ and containing a high concentration of pyridine (the initial concentration above 2.2mol/L).The structures of relative products were characterized.

关 键 词：抗坏血酸 磷酸酯镁 合成 维生素C 

分 类 号：TQ466.3[化学工程—制药化工]