老年急性脑梗塞患者血清C反应蛋白、脂蛋白(a)和纤维蛋白原含量的检测及临床意义  

Detection of serum C-reactive protein,lipoprotein(a) and fibrinogen levels in elderly patients with acute cerebral infarction and clinical significance

作　　者：杨文[1] 沙春蕊[2] 刘柏辉[1] 张艳华[1] 吕贺[1] 于艳春[3] 季有梅[3] 徐丹[3] 许桂英[3] 

机构地区：[1]吉林大学第二医院综合内科,吉林长春130041 [2]吉林大学第二医院麻醉科,吉林长春130041 [3]吉林大学第二医院民康医院,吉林长春130041

出　　处：《吉林大学学报（医学版）》2007年第6期1066-1069,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅重点项目资助课题(200505128)

摘　　要：目的:探讨老年急性脑梗塞与血清C反应蛋白(CRP)、脂蛋白(a)[LP(a)]和纤维蛋白原(FG)的关系。方法:选择老年急性脑梗塞患者106例,采用免疫比浊法于入院当天测定CRP、LP(a)及FG含量。同时选择性别和年龄相似的健康老年人70例作为对照组。比较不同程度和不同梗塞面积老年急性脑梗塞患者血清CRP、LP(a)和FG水平。结果:①老年急性脑梗塞组CRP、LP(a)和FG分别为(14.06±2.17)mg.L-1、(322.34±6.31)mg.L-1和(8.24±2.62)g.L-1,与对照组比较差异有显著性(P<0.05)。②不同梗塞面积的老年急性脑梗塞患者组间CRP、LP(a)和FG水平呈现大梗塞灶>小梗塞灶>腔隙性梗塞,差异具有显著性(P<0.05或P<0.01)。③不同严重程度老年急性脑梗塞患者组间CRP、LP(a)和FG水平为重型>中型>轻型,差异具有显著性(P<0.05或P<0.01)。结论:老年急性脑梗塞的发生与血清CRP、LP(a)和FG水平关系密切。CRP、LP(a)和FG水平越高,梗塞面积越大、病情程度越严重。CRP、LP(a)和FG可作为老年急性脑梗塞的危险因素,并可预测梗塞面积和病情的严重程度。Objective To investigate the relationship between the serum C-reative protein （CRP）, lipoprotein （a） [-LP （a）] fibrinogen （FG） and elderly acute cerebral infarction. Methods 106 elderly patients and 70 healthy elderly persons as control were enrolled in this study. The serum CRP, LP （a） and FG levels were determined with immunoturbidimetry and compared among various severe degree and infarct size groups. Results ①Compared with control group, the serum CRP, LP （a） and FG levels in elderly acute cerebral infarction group increased significantly; they were （14. 06 ±2.17 ） mg· L^-1, （322.34±6.31） mg· L^-1and （8.24±2.62） g · L^-1, respectively （P〈0.05）. ② The serum CRP, LP （a） and FG levels were different among various infarct size groups, large infarct size group〉 small infarct size group〉 lacunar infarction group （P〈 0.05 or P 〈 0.01） . ③The serum CRP, LP （a）, FG levels were different among various severe degree groups, serious group,midrange group〉mild group （P〈0.05 or P〈0.01）. Conclusion The relationship between the serum CRP, LP（a） and FG levels and degree of acute cerebral infarction in elderly patients is intimate. The higher the serum CRP, LP （a） and FG levels were, the larger the infarct size and the more severe the pathogenetic condition. So the serum CRP, LP （a） and FG levels are risk factors for acute cerebral infarction and used to evaluate the severity and infarct size of acute cerebral infarction in elderly patients.

关 键 词：脑梗塞/诊断 脂蛋白(A)/诊断应用 C反应蛋白/诊断应用 纤维蛋白原/诊断应用 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]