ICTP、OC在肺癌骨转移中的应用  

Usefulness of Serum ICTP and OC for Detection of Bone Metastases in Lung Cancer Patients

作　　者：章火祥[1] 于小妹[1] 钭春风[1] 王丽君[1] 

机构地区：[1]浙江医院,浙江杭州310013

出　　处：《实用医技杂志》2007年第24期3243-3245,共3页Journal of Practical Medical Techniques

摘　　要：目的：探讨骨胶原吸收指标血清Ⅰ型胶原吡啶交联终肽（ICTP）和骨形成指标血清骨钙素（Ostccalcin，OC）两者在诊断肺癌骨转移的价值，为肺癌骨转移的诊断提供新的实验室指标。方法：收集我院肿瘤干科门诊及病房经病理确诊的肺癌病人血清65例，通过影像学诊断，将它们分为骨末转移组和骨转移组。并征集我院健康体检人群41例作为正常对照组，分别定量测定血清ICTP，OC浓度。结果：血清ICTP值肺癌骨转移组较肺癌骨末转移组差异有极显著性（P（0．01），肺癌骨末转移组较正常对照组差异亦有极显著性（P〈01），而血清OC值肺癌胃未转移组较正常对照组以及肺癌骨转移组较肺癌骨末转移组差异均无显著性（P〉05）。血清ICTP在诊断肺癌骨转移的敏感度为77．8％，特异度为98．2％，而血清OC在诊断肺癌骨转移的敏感度为11、1％，特异度为85．7％，两者联合诊断肺癌骨转移的敏感度为80．3％，特异度为84．2％。结论：血清ICTP在诊断肺癌骨转移中是特异性高，敏感度较好的有用指标。血清OC在诊断肺癌骨转移中单独使用敏感度不够，意义不大。可根据需要单独或联合应用，作为除影像学外诊断肺癌骨转移有用的实验室诊断指标。Objective To investigate values of serum marker of bone resorption,ICTP and marker of bone formation, osteoealein （OC）in diagnosing bone metastastes with lung cancer patients.Methods Based on seintigraphie and radiological findings ,patients were divided into 3 groups ： 9 lung cancer patients with bone metastasts,56 lung cancer patients without bone metastasts,and 41 normal individuals as eomparisions.Serum ICTP and OC concentrations were assessed for them. Results Serum ICTP were significantly higher in lung cancer patients with bone metastasts compared to both lung cancer patients without skeletal recurrence and those with normal individuals （P〈0.01）.Serum ICTP were also significantly higher in lung cancer patients without bone metastasts compared to those with normal individuals （P〈0.01）.While serum OC were no statistically differences between them （P〉05）.The clinical sensitivity for diagnosing bone metastasts was 77.8% for ICTP, 11.1% for OC,respeetively.The clinical specificity for diserimiuating patients with bone disease from those without were 98.2% for ICTP,85.7% for OC.If taken jointly, the clinical sensitivity were 80.3%,and specificity were 84.2%.Conclusion Serum ICTP is the high clinical specificity and sensitivity in diagnosing in lung cancer patients with bone metastases,while serum OC does not seem to be sufficient in sensitivity and seems to be no use in diagnosing.But if taken singly or jointly,they can be the better laboratory markers in diagnosing bone metastases with lung cancer patients besides radiologieal diagnosis.

关 键 词：Ⅰ型胶原吡啶交联终肽 骨钙素 肺癌 骨转移 

分 类 号：R734.2[医药卫生—肿瘤]