胆囊结石与大肠癌的相关性研究  

The study of the relationship between gallstones and colorectal cancer

作　　者：陈曼彤[1] 

机构地区：[1]广东省佛山市第一人民医院消化内科,528000

出　　处：《中国医师进修杂志（内科版）》2007年第12期11-12,33,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨胆囊结石是否能增加大肠癌发生的危险性。方法应用回顾性分析的方法，比较大肠癌患者1880例（大肠癌组）与健康体检者631例（对照组）中胆囊结石患病率，比较胆囊结石患者5663例（胆囊结石组）与原发性高血压患者27581例（高血压组）、慢性胃炎患者11569例（慢性胃炎组）中大肠癌的患病率，并对大肠癌发生部位、性别等因素进行分析。结果（1）大肠癌组胆囊结石患病率为11．06％，对照组胆囊结石患病率为7．13％，两组比较差异有统计学意义∽=8．063，P=0．005）。（2）大肠癌组结肠癌与直肠癌、男性与女性胆囊结石患病率比较，差异均无统计学意义。（3）胆囊结石组大肠癌患病率为3．67％，高血压组大肠癌患病率为0．77％，慢性胃炎组大肠癌患病率为1．15％，胆囊结石组与高血压组和慢性胃炎组大肠癌患病率比较，差异均有统计学意义（χ^2=317．701，P=0．000；P=124．802，P=0．000）。结论胆囊结石可能导致大肠癌发生的危险性增加。Objective To investigate whether gallstones increases the risk of colorectal cancer. Methods A retrospective case-control study was made on a large sample for colorectal cancer patients and gallstones patients. The attack rates of gallstones in 1880 colorectal cancer cases （colorectal cancer group） and 631 normal controls （control group） were compared. The attack rates of colorectal cancer in 5663 gall- stones cases （gallstones group）,27 581 hypertension cases （hypertension group）,and 11 569 chronic gastritis cases （chronic gastritis group） were compared. Other factors such as position of cancer and sex were considered respectively. Results （ 1 ）The attack rate of gallstones in colorectal cancer group was 11.06%, and control group was 7.13% （χ^2= 8.063,P = 0.005 ）. （2） In the colorectal cancer group, position of cancer and sex would not influence the incidence of gallstones. （3） The attack rates of colorectal cancer in gallstones group,hypertension group, and chronic gastritis group were 3.67% ,0.77% ,and 1.15% ,respectively （χ^2=317.701 ,P = 0.000; χ^2 = 124.802,P = 0.000）. Conclusion Gallstones maybe an increased risk factor of colorectal cancer.

关 键 词：大肠癌 胆囊结石 

分 类 号：R735.34[医药卫生—肿瘤]