6类降压药固定低剂量的单药降压疗效比较  

6 Classes of Low-dosage of Antihypertensive Agents for Essential Hypertension

作　　者：华丛笑[1] 华潞[1] 李娜[1] 王莉[1] 庞会敏[1] 明广华[1] 黄岩[1] 成小如[1] 刘红[1] 吴瑛[1] 许莉[1] 康健[1] 顼志敏[1] 李一石[1] 

机构地区：[1]中国协和医科大学,中国医学科学院,北京阜外心血管病医院,卫生部心血管药物临床研究重点实验室,北京市100037

出　　处：《中国药房》2007年第35期2762-2764,共3页China Pharmacy

摘　　要：目的:为医师选择降压药提供参考。方法:比较370例原发性高血压患者应用6类15种单药治疗的降压疗效。结果:除多沙唑嗪外,各单药均有效降压;多沙唑嗪和托拉塞米降舒张压的效果较逊。结论:长效钙拮抗药、血管紧张素转换酶抑制剂、血管紧张素受体拮抗药以及特拉唑嗪、吲达帕胺均能单药有效降压。低剂量多沙唑嗪和托拉塞米不建议单独使用治疗高血压。OBJECTIVE： To provide references for clinicians in the choice of antihypertensive drugs.METHODS： The antihypertensive efficacy 6 classes（or 15 kinds） of antihypertensive drugs in a monotherapy in the treatment of 370 patients with essential hypertension（EH） were compared.RESULTS： The blood pressure was effectively lowered by all of the antihypertensive drugs except doxazosin, and doxazosin and torasemide showed inferior efficacy in the reduction of diastolic blood pressure （DBP） .CONCLUSION：Calcium antagonists with prolonged action,angiotensin converting enzyme inhibitor（ACEI）,angiotensin receptor antagonist,and the monotherapy of Terazosin or Indapamide can all effectively bring down the blood pressure.It is suggested that low- dose doxazosin and torasernide should not be used alone in treating essential hypertension.

关 键 词：原发性高血压 降压药 单药治疗 

分 类 号：R972.5[医药卫生—药品] R969.4[医药卫生—药学]