单纯前列腺上皮内瘤回顾性分析(附142例病例分析)  

The clinical and pathological analysis of prostatic intraepithelial neoplasia

作　　者：李亚南[1] 毕向军[1] 陈晓清[1] 张晓峰[1] 肖丽萍[1] 余新沛[1] 刘岗[1] 杨明常[1] 宋骤[1] 

机构地区：[1]广州军区广州总医院干部病房二科,广州510010

出　　处：《中国男科学杂志》2007年第11期20-23,共4页Chinese Journal of Andrology

摘　　要：目的通过对前列腺上皮内瘤(PIN)临床资料分析,探讨PIN的生物特性及应对策略。方法对31例无前列腺癌PIN(NPCaPIN)改变患者(其中1级23例,2、3级8例)的临床资料(包括患者血清PSA、fPSA/tPSA、PSA密度等区域计数资料以及穿刺标本免疫组织化学染色结果)进行回顾性分析,以同期确诊为前列腺癌(PCa)、良性前列腺增生(BPH)患者资料作为对照,分析低级别PIN(LGPIN)和高级别PIN(HGPIN)改变之间及NPCaPIN临床特征与PCa、BPH患者临床特征的差异。结果LGPIN和HGPIN改变的患者之间血清PSA水平和年龄存在差异(P<0.05);LGPIN和PCa患者之间血清PSA水平、前列腺体积、fPSA存在显著差异(P<0.01),PSA密度、fPSA/tPSA比值存在差异(P<0.05),和BPH患者之间各项均无明显差异;HGPIN改变和PCa患者之间前列腺体积、fPSA水平和年龄存在差异(P<0.05),和BPH患者之间血清PSA水平差异显著(P<0.01),fPSA/tPSA比值和年龄(P<0.05)存在差异;NPCaPIN和PCa患者之间血清前列腺体积、fPSA水平和年龄、血清PSA水平、PSA密度存在显著差异(P<0.01),和BPH患者之间fPSA/tPSA比值(P<0.05)存在差异。P63、AE1、AE3、P504S、PSA免疫组织化学结果NPCaPIN组类似于BPH而完全异于PCa。结论LGPIN的临床和病理特征与BPH相似,而HGPIN的临床和病理方面具有一定的前列腺恶性肿瘤特征,需要积极的临床追踪观察。Objective To analyze the clinical material and pathology of prostatic intraepithelial neoplasia（PIN）and compared with prostatic cancer（PCa） and benign prostate hyperplasia（BPH）. Methods 31 cases were diagnosed as non-cancer PIN by prostatic biopsy, including 23 cases of grade 1 as low grade PIN（LGPIN） and 8 cases of grade 2 and 3 as high grade PIN（HGPIN）. The data including serum prostate specific antigen（PSA）, free PSA（fPSA） and fPSA/tPSA, PSA density（PSAD）, immunochemical detection were analyzed and compared with PCa and BPH. Results Differences of serum PSA and average age were found between LGPIN and HGPIN patients（P〈0.05）. Serum PSA, fPSA, fPSA/tPSA, PSAD, prostate volume were all markedly different between patients from LGPIN and PCa. No obvious difference was observed between patients from LGPIN and BPH. Serum fPSA and prostate volume, age were different between patients from HGPIN and PC. Serum PSA and fPSA/tPSA were different between patients from HGPIN and BPH. Difference of fPSA/tPSA was observed between patients from non-cancer PIN and BPH. Serum PSA, fPSA, age, PSAD, prostate volume were all markedly different between patients from non-cancer PIN and PCa. Immunochemical assay shew P63、AE1、AE3、 P504S、PSA expressed in non-cancer PIN were closely similar with BPH and totally adverse to PCa. Conclusion LGPIN holds similar clinical and pathological features with BPH. HGPIN show some malignant characters and should be traced.

关 键 词：前列腺肿瘤 前列腺上皮内瘤病 前列腺增生 回顾性研究 

分 类 号：R737.25[医药卫生—肿瘤]