单侧苍白球毁损术治疗不同类型帕金森病的疗效分析  

Efficacies of unilateral pallidotomy for the treatment of Parkinson's disease of different types

作　　者：石长青[1] 武剑[2] 

机构地区：[1]首都医科大学宣武医院神经外科,北京100053 [2]首都医科大学宣武医院神经内科,北京100053

出　　处：《中华神经医学杂志》2007年第12期1221-1223,共3页Chinese Journal of Neuromedicine

摘　　要：目的评价单侧苍白球腹后部毁损术对两种不同类型的帕金森病的近期和远期疗效。方法应用做电极导向技术对46例帕金森病患者实施了单侧苍白球腹后部毁损术,其中震颤型20例和僵直迟缓型26例。采用"关状态"UPDRSⅢ评分对术后1月和术后1年的患者进行疗效评价并分析结果。结果单侧苍白球腹后部毁损术对两组患者运动症状的近期改善率平均为59%和56%,经一年随访分别下降为54%和17%。结论单侧苍白球腹后部毁损术稳定地改善震颤型帕金森病,而对僵直迟缓型帕金森病的疗效不稳定,远期疗效较差。Objective To evaluate the short-term and long-term outcomes of unilateral posteroventral pallidotomy （UPVP） for the treatment of two different types of Parkinson＇ s disease （PD）. Methods The microeleetrode-guided technique was applied to perform UPVP on 46 cases with PD, including 20 cases of tremor-dominant PD and 26 cases of rigidity-bradykinesia-dominant PD. Subscale Ⅲ data of the unified PD rating scale （UPDRS） in the ＂off-state＂ was used to evaluate the efficacies respectively after at 1 month and 1 year after the operation had been performed on the patients, and results were analyzed. Results The average short-term improvement rates of UPVP on the patients with tremor-dominant PD and rigidity-bradykinesia-dominant PD were respectively 59% and 56%, but declined to 54% and 17% respectively after one-year follow-up. Conclusion The effect of UPVP on patients with tremor-dominant PD is stable and long-lasting; the efficacy of UPVP on rigidity-bradykinesia-dominant PD is not stable and the long-term outcome is poor.

关 键 词：帕金森病 苍白球腹后部毁损术 

分 类 号：R742.5[医药卫生—神经病学与精神病学]