磁性微胶囊的制备及其药物缓控释性能  

Preparation and Controlled Drug Release Properties of Magnetic Microcapsules

作　　者：李琳琳[1] 陈东[1] 丁明慧[1] 唐芳琼[1] 孟宪伟[1] 任俊[1] 张琳[1] 

机构地区：[1]中国科学院理化技术研究所

出　　处：《物理化学学报》2007年第12期1969-1973,共5页Acta Physico-Chimica Sinica

基　　金：国家863计划(2006AA03Z322);国家自然科学基金(20571080);北京市自然科学基金(2063033);中国科学院创新基金(kjcx2-sw-h12-01)资助

摘　　要：用乳液-凝胶法制备了磁性壳聚糖/海藻酸钠微胶囊.在壳聚糖/海藻酸钠微胶囊中掺入Fe3O4磁性中空球,使微胶囊具有磁靶向性能.以头孢拉定作为模型药物研究了载药磁性微胶囊的载药量、包封率及药物缓控释性能等.结果表明,提高头孢拉定的初始浓度可以提高载药量,却不利于提高药物的包封率.所制备的微胶囊在各种缓冲溶液中长时间内具有显著的缓释效果,并具有pH刺激响应释放的性能,即在模拟胃液中的药物释放率大大降低,而在模拟体液和肠液中的释放时间大大延长,可达50h以上.另外,在外加磁场作用下,微胶囊表现出良好的磁定向运动性能,为磁靶向药物输送提供基础.Magnetic chitosan-alginate microcapsules were prepared via emulsion-gel method. Fe3O4 magnetic hollow spheres were capsulated into the microcapsules, which endowed the microcapsules with magnetic targeting properties. Cefradine was used as model drug to study the properties of the microcapsules including drug content, encapsulation efficiency, and controlled drug release. The results showed that with the increasing of initial drug concentration, the drug content increased, but the encapsulation efficiency decreased. The microcapsules exhibited sustained release of the drug in all media and the release rate could be regulated by the pH value： in simulated gastric fluid, the release rate was greatly decreased, and in simulated body fluid and intestinal fluid, the microcapsules exhibited a constant release in 50 h with different release rates. Under an external magnetic field, the microcapsules showed fine magnetic response properties, which provided possibility for magnetic targeting drug delivery.

关 键 词：微胶囊 磁靶向 药物缓控释 磁性中空球 pH刺激响应 壳聚糖 

分 类 号：TQ460[化学工程—制药化工]