2型糖尿病并发脑梗死患者血清肝细胞生长因子水平及临床意义  

Serum Levels of HGF and Its Clinical Significance in Type 2 Diabetes Mellitus Patients with Cerebral Infarction

作　　者：尤志珺[1] 汪健[1] 周少华[1] 席刚明[1] 

机构地区：[1]郧阳医学院附属十堰市人民医院神经内科,湖北十堰442000

出　　处：《神经损伤与功能重建》2007年第6期352-354,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨2型糖尿病并发脑梗死患者血清肝细胞生长因子(HGF)的水平及临床意义。方法:采用双抗体酶联免疫吸附法(ELISA)测定30例2型糖尿病并发脑梗死患者(A组)急性期(入院第2天)、恢复期(发病第40天)和30例无脑梗死的2型糖尿病患者(B组)、30例健康体检者(C组)的血清HGF浓度。结果:各组血清HGF浓度比较,A组急性期明显高于B组(t=5.05,P<0.01)和C组(t=8.81,P<0.01),B组亦高于C组(t= 2.41,P<0.05),但A组恢复期与C组比较差异无统计学意义(t=1.97,P>0.05)。结论:HGF作为神经营养因子参与了2型糖尿病并发脑梗死后脑损伤的修复。Objective： To investigate serum levels of Hepatocyte growth factor （HGF） and its clinical significance in type 2 diabetic patients with cerebral infarction. Methods： The serum levels of HGF in 30 patients with type 2 diabetes mellitus and acute cerebral infarction （group A）, 30 patients with type 2 diabetic patients without cerebral infarction （group B） and 30 healthy persons were examined. Results： The levels of HGF in the patients in group A were significantly higher than those in group B （P〈0.01） and in group C（P〈0.01）. The levels of HGF in group B were obviously higher than those in group C （P〈0.05）, but without obvious difference between group A in recovery phase and group C（P〉0.05）. Conclusion： HGF is related to the pathogenesis of strokes and may reflect the severity of atherosclerosis of type 2 diabetic patients with cerebral infarction.

关 键 词：脑梗死 2型糖尿病 肝细胞生长因子 

分 类 号：R741[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]