22例眼眶转移癌临床病理分析  

The clinicopathologic analysis of 22 cases of metastatic orbital tumors

作　　者：黑砚[1] 康莉[1] 李月月[1] 鲁小中[1] 魏红[1] 肖利华[1] 

机构地区：[1]武警总医院眼眶病研究所,北京100039

出　　处：《眼科》2007年第6期403-406,共4页Ophthalmology in China

摘　　要：目的探讨眼眶转移癌的临床特征和原发部位。设计回顾性病例系列。研究对象22例眼眶转移癌患者。方法分析1999～2007年武警总医院眼眶病研究所22例眼眶转移癌患者的临床、影像学和病理诊断资料。主要指标临床表现、影像学表现、病理形态学表现、原发部位。结果22例眼眶转移性肿瘤中原发肿瘤来自乳腺6例(27.3%),肺癌5例(22.7%),来源未明低分化腺癌3例(13.6%),肝癌2例(9.1%),甲状腺癌、宫颈癌、直肠类癌、下肢恶性黑色素瘤、腹膜后恶性副神经节细胞瘤及神经母细胞瘤各1例。女性13例,男性9例,平均年龄50.2岁(中位数年龄51岁,范围6～67岁)。病变位于右眼眶11例,左眼眶5例,双侧眼眶1例,同侧眼内加眶内转移2例,眶颅沟通3例。最常见的症状为视力下降、其次是眼球运动不良、眼球突出、眼痛和眼睑肿胀。10例(45.5%)眼部表现是首发症状,3例(13.6%)未找到原发灶。结论眼眶转移性肿瘤来自乳腺占第一位,其次是肺癌和来源不明的低分化腺癌。部分病例眼部症状为首发症状。(眼科,2007,16:403-406)Objective To study the clinicopathologic characteristics and the primary position of metastatic orbital tumors. Design Retrospective case series. Participants Twenty-two patients with metastatic orbital tumor. Methods The clinical, imaging and histopathological data of 22 patients with metastatic orbital tumors, treated in our bospital from 1999 to 2007 were reviewed. Main Outcome Measures The clinical, imaging and histopathological manifestations, the primary position of tumor. Results There were 6 cases （27.3%） arising from breast cancer, 5 cases （22.7%） derived from lungs cancer, 3 cases （13.6%） from unknown primary position with poorly differentiated adenocarcinoma, 2 cases （9.1%） from liver cancer. The primary tumor was thyroid carcinoma, cervical carcinoma, rectal carcinoid, lower extremity malignant melanoma, retroperitoneal malignant paraganglioma, adrenal neuroblastoma in 1 case each. There were 13 female patients and 9 male patients whose mean age at diagnosis was 50.2 years （median 51 years, ranged from 6 to 67 years older ）. In all 22 cases, 11 cases with metastatic tumors was in right orbit, 5 cases in left orbit, and I case in bilateral orbits. Two cases were simultaneous in choroid and orbit, 3 cases were orbito-cranial communicating tumors. The most frequent ocular signs were decreased visual acuity, exophthalmos, limited ocular movement, ocular pain and lid swelling. There was no history, of malignant tumor at the time of presentation in 10 cases （45.5%）. In 3 cases （13.6%）, the primary tumor remained undetected despite systemic evaluation. Conclusions Most of the metastatic orbital tumors are from breast cancer;, followed with lung cancer and tumor unknown primary position. Ocular signs are noted prior to diagnosis of the primary lesion in part of cases. （Ophthalmol CHN, 2007, 16： 403-406）

关 键 词：眼眶转移性肿瘤 病理诊断 特征 原发部位 病例 

分 类 号：R739.7[医药卫生—肿瘤]