艾迪注射液联合FOLFOX4化疗治疗晚期大肠癌的临床观察  

Comparative Study on Treatment of Advanced Colorectal Cancer by Aidi Injection Combined with FOLFOX4 Regimen and by FOLFOX4 Regimen Alone

作　　者：李海金[1] 董良[1] 符淑媛[2] 李英[1] 

机构地区：[1]中国医科大学华宇医院肿瘤内科,浙江312030 [2]锦州医学院附属医院肿瘤内科

出　　处：《中国中西医结合杂志》2007年第12期1086-1089,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察艾迪注射液联合FOLFOX4化疗治疗晚期大肠癌的近期疗效和不良反应。方法将117例大肠癌患者随机分两组,对照组52例,单用FOLFOX4化疗方案,用法:奥沙利铂85 mg/m^2静脉滴入2 h,第1天,亚叶酸钙200 mg/m^2静脉滴注2 h,第1、2天,5-氟脲嘧啶400 mg/m^2静脉推注,第1,2天,600 mg/m^2持续微泵推入22 h,第1、2天,14天为1个周期。治疗组65例,在对照组治疗基础上加用艾迪注射液60 mL加入5%葡萄糖注射液250 mL中静脉滴注,连用10天。结果治疗组和对照组有效率分别是44.62%、30.77%(P=0.126),KPS评分改善率分别是66.15%、40.38%(P=0.005),1年生存率分别是53.85%、40.38%(P=0.148),不良反应治疗组明显少于对照组(P<0.05)。结论艾迪注射液联合FOL- FOX4方案治疗晚期大肠癌,较单用FOLFOX4方案治疗疗效好,不良反应轻,生活质量改善明显,生存期有所延长。Objective To evaluate the therapeutic efficacy and adverse reaction of Aidi Injection （ADI） combined with FOLFOX4 regimen for treatment of patients with advanced colorectal cancer, and controlled with those of FOLFOX4 regimen alone. Methods One hundred and seventeen patients were randomized into two groups. All received FOLFOX4 regimen, i.e. Oxaliplatin 85 mg/m2 intravenous dripping in 2 h on day 1, leucovorin CF 200 mg/m2 intravenous dripping and 5-FU 400 mg/m2 intravenous injection followed with 600 mg/m2 continuous infusion by micro-pump in 22 h on day 1 and 2, 14 days as one cycle. Besides, to the treatment group （65 patients）, ADI was administered additionally by adding 60 mL ADI in 250 mL 5 % glucose for intravenous dripping every day for 10 successive days, while to the control group （52 patients）, no additional medication was given. Results The response rate in the treatment group was 44.62%, and in the control group 30.77 % （P= 0. 126）, the KPS score improving rate in the two groups was 66.15 % and 40.38 % respectively （P = 0.005）, the 1-year survival rate was 53.85 % and 40.38 % respectively （P = 0. 148）, and the adverse reaction presented in the treatment group was greatly less than that in the control group （P （0.05）. Conclusion ADI in combining with FOLFOX4 regimen can enhance the efficacy, reduce the adverse reaction of chemotherapy in treating advanced colorectal cancer, and could also improve the quality of life and prolong the survival time of patients.

关 键 词：艾迪注射液 FOLFOX4化疗方案 大肠癌 化学治疗 不良反应 

分 类 号：R735.34[医药卫生—肿瘤]