主客体包结法选择分离青花椒挥发油中的化学成分  

Selective Isolation of Components of Volatile Oil of Zanthoxylum Schinifolium Sieb.et Zucc Using Inclusion Crystallization of Host and Guest

作　　者：郭文生[1] 王忠华[1] 郭放[1] 胡志泉[1] 张爽[1] 徐赫男[2] 常键 刘成雁 

机构地区：[1]辽宁大学化学科学与工程学院,沈阳110036 [2]郑州大学化学系 [3]辽宁省分析测试研究院,沈阳110015

出　　处：《化学学报》2007年第23期2731-2737,共7页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20372031)资助项目.

摘　　要：以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子,可简单、迅速地从青椒挥发油中选择分离出化学成分烯丙基茴香醚,基于挥发油的用量,收率为3.78%.IR,1HNMR,13CNMR光谱和单晶衍射证实了包结化合物结构,用气相色谱法评价了选择分离效果,分离的烯丙基茴香醚气相色谱纯度为94.5%.同时,主体分子形成的隧道框架对茴香醛具有识别作用,形成2∶1(主/客)物质的量比的特殊结构包结物晶体,它是主客体分子物质的量比为1∶2包结物的超分子异构体.1,1,6,6-Tetraphenylhexa-2,4-diyne-1,6-diol as host could selectively isolate 4-allylanisole from the crude volatile oil of Zanthoxylum schinifolium Sieb.et Zucc simply and rapidly, with a yeild of 3.78% based on the amount of volatile oil used. Inclusion compound structure was confirmed by IR, ^1 H NMR, ^13 C NMR and single crystal X-ray diffraction. Gas chromatographic method was used to assess the isolation effect and gas chromatographic purity of 4-allylanisole separated is 94.5%. At the same time, the channel framework formed by hosts could recognize p-anisaldehyde and form exceptive structural inclusion compound at a molar ratio of 2 ： 1 （host/guest）, which is a supramolecular isomer of inclusion compound at a molar ratio of 1 ： 2 （host/guest）.

关 键 词：青花椒 包结化合物 选择分离 烯丙基茴香醚 茴香醛 

分 类 号：TQ461[化学工程—制药化工]