消痞颗粒治疗功能性消化不良的临床研究  

Clinical study of Xiaopi Granule on patients with functional dyspepsia

作　　者：张亚声[1] 王松坡[1] 陈怀红[1] 张存钧[1] 张镜人[1] 

机构地区：[1]上海交通大学附属第一人民医院中医科,上海200080

出　　处：《中成药》2007年第12期1733-1735,共3页Chinese Traditional Patent Medicine

基　　金：上海市科学技术委员会基金资助项目(No.04dz19858)

摘　　要：目的:观察张镜人教授痞满证经验方—消痞颗粒(地枯萝、生白术、苏梗、香附、砂仁、黄芩、广郁金、元胡)对功能性消化不良(FD)患者的疗效并从血浆胃动素水平探讨其作用机制。方法:入选FD患者71例,随机分为治疗组36例,对照组35例。前者消痞颗粒治疗,对照组服用西沙必利。观察两组患者的症状改善情况并检测治疗前后的血浆胃动素水平。结果:消痞颗粒对FD患者疗效与对照组相近(P>0.05)。就单个症状而言,消痞颗粒对上腹疼痛的改善显著优于对照(P<0.05)。消痞颗粒能明显提高FD患者血浆胃动素水平(P<0.01)。结论:消痞颗粒能改善FD患者症状,对血浆胃动素水平的改善可能是其取效的机制之一。AIM： To investigate the clinical effectiveness of Xiaopi Granule （XPG） （Radix Raphani ; Rhizoma Atractylodis macrocephalae, Caulis Perillae, Rhizoma Cyperi, Fructus Amomi, Radix Scutella-riae, Radix Curcumae, Rhizoma Corydalis） on patients with functional dyspepsia （FD） and approach its possible mechanism on plasma motilin. METHODS： 71 FD patients were divided into 2 groups randomly： treatment group （36 patients） and control group （35 patients）. The treatment group patients were treated with XPC, while the control group were treated with cisapride. To observe the improvement of symptoms, and measure the plasma motilin level before and after treatment. RESULTS： XPG and cisapride can improve the symptoms in FD patients significantly, but there is no difference between two groups （P 〉0.05）. XPG can improve the upper abdominal pain,which was better than that of the control group （P 〈 0.05 ）. XPG can increase the plasma motilin level in FD patients significantly （ P 〈 0.01 ）. CONCLUSION： XPG can improve the symptoms in FD, and increase plasma motilin level which is one of the mechanisms probably.

关 键 词：消痞颗粒 功能性消化不良 胃动素 中医药疗法 

分 类 号：R57[医药卫生—消化系统]