抑郁症患者的APOE基因多态性及血脂水平的研究  

Apolipoprotein E gene polymorphisms and serum lipid characteristics in depressive patients

作　　者：焦玉梅[1] 宋立升[1] 刘燕[1] 汪栋祥[1] 王立伟[2] 章连生[1] 禹顺英[1] 施慎逊[2] 

机构地区：[1]上海市精神卫生中心,201108 [2]复旦大学附属华山医院精神医学教研室

出　　处：《上海精神医学》2007年第6期326-330,共5页Shanghai Archives of Psychiatry

摘　　要：目的探索载脂蛋白E(apolipoprotein E,APOE)基因多态性与抑郁症之间的关系及其对抑郁症患者脂代谢的影响。方法对92例符合中国精神障碍分类与诊断第三版(CCMD-3)抑郁发作的患者和60例正常对照进行APOE基因分型、测量他们的体重、身高、腰围、臀围,并测定血脂水平,包括总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)。以17项汉密尔顿抑郁量表(HAMD17)和汉密尔顿焦虑量表(HAMA)评定抑郁症患者的抑郁、焦虑症状。结果抑郁症与对照组间APOE基因型及等位基因频率无显著差异。抑郁症组中,携带APOEε4等位基因的患者平均TC显著高于不携带APOEε4等位基因的患者,差异有统计学意义(P(0.05)。对照组中,携带APOEε4等位基因者与不携带APOEε4等位基因者相比,体质参数、血脂平均值均无差异(P(0.05)。携带和不携带APOEε4等位基因的抑郁症患者TG值均分别高于携带和不携带APOEε4等位基因的对照组TG值,差异有显著性(P(0.05,P(0.01);携带和不携带APOEε4等位基因的抑郁症患者的HDL值分别比对照组相应者低,差异有显著性(P(0.01,P(0.001);携带APOEε4等位基因的抑郁症患者的HAMD17阻滞项评分高于不携带此等位基因的抑郁症患者,差异有显著性(P(0.05)。结论抑郁症与APOE基因多态性无明显关联。抑郁症患者存在一定的血脂紊乱,尤其是携带APOEε4等位基因的抑郁症患者可能有更多的血脂代谢问题,而且携带APOEε4等位基因的抑郁症患者HAMD17阻滞项评分较高。Objective： To investigate the association of apolipoprotein E （APOE） gene polymorphisms with depression and the genes influence on fasting serum lipid in depressive patients. Methods： The genotypes and alleles of APOE gene polymorphisms in 92 depressive patients and 60 healthy controls were examined and compared. The height,body weight, waist circumference,hip circumference,total cholesterol（TC） , triglyceride （TG） ,high density lipoprotein cholesterol （HDL）,low density lipoprotein cholesterol （LDL） were examined. HAMD17 and HAMA were used to assess the symptoms of the major depressive patients. Results： The polymorphisms of APOE gene were not associated with depression. The depressive patients with APOEε4 allele had significantly higher level of TC compared with those of patients without it（P 〈 0.05）. But there were no significant differences between APOEε4 allele carriers and non - carriers in control group in the levels of the all lipid profiles （P 〉 0. 05 ）. Compared with the controls who carried APOEε4 allele and not carried, the depression patients who carried APOEε4 allele and not carried had higher TG levels respectively（ P 〈 0.05 and P 〈 0, 01 ）, The depression patients with or without APOEε4 allele had significantly lower level of HDL than those of controls who carried APOEε4 allele and not carried respectively （P 〈 0.01 and P 〈 0. 001 ）. The depression patients with APOEε4 allele had significantly higher retardation scores of HAMD than those without it （P 〈 0, 05 ）. Conclusion：The polymorphisms of APOE gene were not associated with depression, The depressive patients, especially the patients who carried the APOEε4 allele had more disturbances in lipid metabolism and higher retardation scores of HAMD.

关 键 词：抑郁症 APOE基因 多态性 血脂 

分 类 号：R749.4[医药卫生—神经病学与精神病学]