透明质酸在口腔鳞状细胞癌组织中的表达  

Hyaluronan expression in oral squamous cell carcinoma

作　　者：李建华[1] 郝佳[1] 葛丽华[2] 汤晓飞[2] 邢汝东[1] 

机构地区：[1]首都医科大学口腔医学院口腔颌面外科,100050 [2]北京口腔医学研究所

出　　处：《北京口腔医学》2007年第6期310-312,共3页Beijing Journal of Stomatology

基　　金：北京口腔医院院基金资助(20040105)

摘　　要：目的本研究旨在探讨透明质酸在不同分化口腔鳞状细胞癌中的表达及意义。方法应用免疫组织化学法检测37例不同分化程度口腔鳞状细胞癌组织中透明质酸的表达。结果按阴性(-)、弱阳性(+)、阳性(++)、强阳性(+++)表示,并进行统计学分析。结果透明质酸主要表达于肿瘤间质和细胞外基质,细胞膜和胞浆中染色相对较少。37例口腔鳞状细胞癌组织中,低分化鳞癌透明质酸的表达明显高于高分化鳞癌(P<0.05),表达随肿瘤分化程度降低而增强。结论透明质酸的表达与口腔鳞状细胞癌的分化程度有关,分化越低,其表达越强。透明质酸的高表达可能有利于病变的侵袭和转移。Objective To investigate the expression of hyaluronan （HA） in oral squamous cell carcinoma （SCC） and to determine if staining could be correlated with biologic behavior. Methods The expression of hyaluronan in 37 cases of SCC with different differentiations （highly differentiated： 20; poorly differentiated： 17 ） was studied by immunohistochemistry method. The staining was recorded as negative （ - ）, weak positive （ ＋ ）, positive （ ＋＋ ）, and strong positive （ ＋＋＋ ）. The results were statistically analyzed. Results HA was predominantly expressed in tumor stroma, while most tumor cells were negative for HA. In all 37 specimens, poorly differentiated SCC expressed more HA than those with highly differentiated. The level of HA expression in stroma increased along with poor histopathologic differentiation. Conclusion HA was mainly expressed in stroma of SCC, and the level of expression was related to the tumor histopathologic grade. HA staining was more intense in poorly differentiated SCC than in highly differentiated SCC. The strong expression of HA may facilitate the invasion and metastasis of SCC.

关 键 词：透明质酸 鳞状细胞癌 口腔 

分 类 号：R739.8[医药卫生—肿瘤]