DNA-PK与肿瘤放化疗敏感性的关系  

Correlations between DNA-PK and radio/chemo-sensitization of tumor

作　　者：孙建华[1] 陶秀娟[2] 

机构地区：[1]大连医科大学研究生院 [2]辽宁省肿瘤医院生物治疗科,辽宁沈阳110042

出　　处：《大连医科大学学报》2007年第6期597-599,共3页Journal of Dalian Medical University

摘　　要：辐射或药物损伤可致肿瘤细胞DNA双链断裂,而DNA依赖性蛋白激酶(DNA-depended protein kinase,DNA-PK)是DNA损伤修复的关键酶,决定着受损肿瘤细胞的转归。因此,DNA-PK与肿瘤放化疗敏感性的关系成为研究热点。近年来,关于DNA-PK的结构与功能、在肿瘤细胞株中的活性、在肿瘤组织中的表达的研究日益深入,以DNA-PK为靶点的DNA修复抑制剂作为肿瘤放化疗增敏药已陆续研发并进入临床前试验。该综述简要回顾DNA-PK的生物学作用及其研究进展。DNA double - strand breaks （DSBs） are the major lethal lesions in tumor cells induced by ionizing radiation and chemotherapy. DNA - depended protein kinase（ DNA - PK） was considered a critical enzyme in the repair of the DSBs, determining the survival of lethal tumor cells. Activity of DNA - PK, whether in human tumor cell lines or in primary tumor biopsies from patients, was shown to be important for tumor response to radiation, so correlations between DNA -PK protein expression and treatment outcome become a hot spot for research. Today, with its specific structure and function, DNA - PK proves a viable target for radio - sensitization and chemo - sensitization. DNA - PK inhibitors, a kind of novel radiation - sensitizing drugs, were developed and came to pre - clinical trial. This is a review about DNA - PK and its application in radio/chemo - sensitization of tumor.

关 键 词：DNA—PK 肿瘤 放射敏感性 化学治疗 放射治疗 

分 类 号：R730.5[医药卫生—肿瘤]