Novel Antiviral Agents Targeting HIV Entry and Transmission  

作　　者：Qinxue Hu Robin Shattock 

机构地区：[1]Center for Infection, Department of Cellular and Molecular Medicine, St George＇s University of London, London SW17 ORE, UK [2]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

出　　处：《Virologica Sinica》2007年第6期451-461,共11页中国病毒学（英文版）

基　　金：NIH (AI065413 and AI041346);the 973 Program (2006CB504200) for financial support.

摘　　要：Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 interaction,coreceptor binding or viral-cell fusion in preclinical and clinical studies. One of these agents,fusion inhibitor enfuvirtide,is already in clinical use. Here we review the progress in the development of specific entry inhibitors as novel therapeutics. The potential of entry inhibitors as topical microbicides to block HIV transmission is also discussed.Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp 120 interaction, coreceptor binding or viral-cell fusion in preclinical and clinical studies. One of these agents, fusion inhibitor enfuvirtide, is already in clinical use. Here we review the progress in the development of specific entry inhibitors as novel therapeutics. The potential of entry inhibitors as topical microbicides to block HIV transmission is also discussed.

关 键 词：HIV- 1 ENTRY Transmission Antiretroviral therapy MICROBICIDE 

分 类 号：R512.91[医药卫生—内科学] R978.7[医药卫生—临床医学]