Carcinoma cervix is a major cancer of women killing 510,000 women every year worldwide. Human papilloma virus (HPV) infection of cervical cells initiates the transformation of the cervical cells to malignant stage. HP...
the US National Institutes of Health (NIH);CONRAD and Starpharma Pty Ltd;the Microbicide Tri- als Network (MTN-004, Ian McGowan, PI) ; the Ado- lescent Trials Network (ATN-062, Alex Carballo-Diéguez, PI)
Young women are an important target group in microbicide research, yet little is known about why they participate and stay in microbicide trials. Our study examined motivations for participating in a Phase I microbici...
Objectives: (A) HIV prevention, using a mechanical cervical barrier in combination with microbicide. (B) Prevention of pregnancy. (C) Shield the cervix to prevent sperm penetration and Gonorrhea, Chlamydia and HIV vir...
Background To effectively block the invasion of human immunodeficiency virus (HIV)-1 on mucosal surface, vaginal anti-HIV-1 microbicides should avoid inflammatory responses and disruption of mucosa integrity because...
According to Joint United Nations Program on HIV/AIDS (UNAIDS) report in 2009, the estimated number of people living with HIV-1 is 33.4 million, and half of the infected adults (aged 15-49 years) are women, who ac...
NIH (AI065413 and AI041346);the 973 Program (2006CB504200) for financial support.
Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 in...