MICROBICIDES

作品数：6被引量：9H指数：1
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相关领域：医药卫生更多>>
相关作者：刘叔文更多>>
相关机构：南方医科大学更多>>
相关期刊：《Chinese Medical Journal》《World Journal of AIDS》《Advances in Bioscience and Biotechnology》更多>>
相关基金：广州市科技攻关项目更多>>
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The Motivations and Experiences of Young Women in a Microbicide Trial in the USA and Puerto Rico
《World Journal of AIDS》2013年第3期179-186,共8页Rebecca Giguere Gregory DZimet Jessica AKahn Curtis Dolezal Cheng-Shiun Leu Marina Mabragana Ian McGowan Alex Carballo-Dieguez 
the US National Institutes of Health (NIH);CONRAD and Starpharma Pty Ltd;the Microbicide Tri- als Network (MTN-004, Ian McGowan, PI) ; the Ado- lescent Trials Network (ATN-062, Alex Carballo-Diéguez, PI)
Young women are an important target group in microbicide research, yet little is known about why they participate and stay in microbicide trials. Our study examined motivations for participating in a Phase I microbici...
关键词：USA Puerto Rico MICROBICIDES MOTIVATION Research Participation Young Women HIV 
<i>In vitro</i>activity of cationic peptides against <i>Neisseria gonorrhoeae</i>and vaginal <i>Lactobacillus</i>species: The effect of divalent cations被引量：1
《Advances in Bioscience and Biotechnology》2012年第3期249-255,共7页Bernard J. Moncla Timothy A. Mietzner Sharon Louise Hillier 
One of the new strategies for the prevention of HIV acquisition is the use of microbicides such as topical microbicides including antimicrobial and antiviral peptides. Ideally, new drug candidates should kill pathogen...
关键词：MICROBICIDES HIV LACTOBACILLUS Antimicrobial Peptides Cations Neisseria GONORRHOEAE 
Degradation of naturally occurring and engineered antimicrobial peptides by proteases被引量：1
《Advances in Bioscience and Biotechnology》2011年第6期404-408,共5页Bernard J. Moncla Kara Pryke Lisa Cencia Rohan Phillip W. Graebing 
We hypothesized that current antimicrobial peptides should be susceptible to proteolytic digestion. The antimicrobial peptides: Griffithinsin, RC-101, LL-37, LSA-5, PSC-RANTES and DJ007 were degraded by commercially a...
关键词：MICROBICIDES HIV ANTI-HIV ANTIMICROBIAL PEPTIDES Proteases 
Establishing a Th17 based mouse model for preclinical assessment of the toxicity of candidate microbicides被引量：6
《Chinese Medical Journal》2010年第23期3381-3388,共8页LI Liang-zhu YANG Yu YUAN Song-hua WAN Yan-min QIU Chao FENG Yan-ling XU Jian-qing ZHANG Xiao-yan 
Background To effectively block the invasion of human immunodeficiency virus （HIV）-1 on mucosal surface, vaginal anti-HIV-1 microbicides should avoid inflammatory responses and disruption of mucosa integrity because...
关键词：hunman immunodeficiency virus 1 MICROBICIDE inflammatory cytokine murine model NONOXYNOL-9 
HIV microbicides： innovation and challenge
《Chinese Medical Journal》2010年第11期1463-1465,共3页ZHANG Xiao-yan 
According to Joint United Nations Program on HIV/AIDS （UNAIDS） report in 2009, the estimated number of people living with HIV-1 is 33.4 million, and half of the infected adults （aged 15-49 years） are women, who ac...
关键词：HIV-1 MICROBICIDE sexually transmission PREVENTION 
Optimized Benzalkonium Chloride Gel: A Potential Vaginal Microbicides被引量：1
《Journal of Reproduction and Contraception》2007年第2期89-92,共4页Xun-cheng DING Wei-hua LI Jie-fei LI Qiang-yi WANG 
Objective To develop an optimized BZK gel with good pharmaceutical effect and less toxicity to vaginal mucosa. Methods Four methods as below were used to research the spermicidal activity of BZK gel： 1） in vitro spe...
关键词：Benzalkonium Chloride MICROBICIDES CONTRACEPTION HIV/AIDS 
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