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Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo被引量：2: 《Virologica Sinica》2023年第2期285-295,共11页Hanyu Pan Xinyi Yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu; funded by the National Natural Science Foundation of China(81761128020 and 82041001);the National Grand Program on Key Infectious Diseases(2017ZX10202102-002).; HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env proteins.However,T cell exhaustion and the patient-specific autologous paradigm of CAR-...; 关键词：Anti-HIV CAR-T PD-1 blocking TCR disruption Cellular immunotherapy

Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV‑1被引量：7: 《Natural Products and Bioprospecting》2020年第1期37-44,共8页Cheng-Jian Tan Shi-Fei Li Ning Huang Yu Zhang Ying-Tong Di Yong-Tang Zheng Xiao-Jiang Hao; supported financially by grants from the National Science Foundation of China(21432010 and 81660612);Technological leading talent project of Yunnan(2015HA020);Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(2017FE467(-127),Scientific Research Fund Projects from the Department of Education of Yunnan(2016ZDX042);the Hundred-Talent Program of Kunming Medical University(60117190441).; Natural products are the important source for the discovery of more potent anti-HIV agents.In this study,six daphnane diterpenoids including three unreported structures were isolated from Trigonostemon lii,which showe...; 关键词：Trigonostemon lii Daphnane diterpenoid Trigonolactone ANTI-HIV

Anti-HIV lignans from Justicia procumbens被引量：4: 《Chinese Journal of Natural Medicines》2019年第12期945-952,共8页XU Xin-Ya WANG Dong-Ying KU Chuen-Fai ZHAO Yang CHENG Han LIU Kang-Lun RONG Li-Jun ZHANG Hong-Jie; supported by the Research Grants Council of the Hong Kong Special Administrative Region,China(Nos.HKBU12103618 and HKBU12103917);the Research Grants Council of the Hong Kong Baptist University(HKBU);Interdisciplinary Research Matching Scheme(No.RC-IRMS/15-16/02);the Hong Kong Scholars Program Foundation(No.XJ2015047);Mr.Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund(WANG Dong-Ying); Twenty-one lignans including three new ones(1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1 D and 2 D NMR analysis. Th...; 关键词：Justicia procumbens Antiviral plant Lignans Anti-HIV-1 activity

New Anti-HIV Drug Candidate Thioraviroc Approved for Clinical Study: 《Bulletin of the Chinese Academy of Sciences》2019年第3期135-136,共2页YAN Fusheng; On May 5,2019,Thioraviroc,a new anti-HIV drug candidate that binds to CCR5(one of the key co-recepetors for HIV infection),received a clinical trial permission issued by the National Medical Products Administration(NM...; 关键词：HIV STUDY CCR

两种不同全自动酶免检测系统检测性能比对研究: 《江西医药》2019年第5期568-570,共3页彭小华汤明章丹; 目的比较两种不同全自动酶免检测系统检测性能。方法在同一工作环境下,使用相同的质控品作为标本,并用指定厂家试剂对其进行HBsAg、Anti-HCV试、Anti-HIV、Anti-TP检测,一组用Uranus-AE-100全自动酶免分析仪进行检测,另一组用Freedom Ev...; 关键词：全自动酶免检测系统性能对比 HBsAg ANTI-HCV ANTI-HIV ANTI-TP

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5: 《Acta Pharmacologica Sinica》2019年第4期563-568,共6页Ya Zhu Yan-long Zhao Jian Li Hong Liu Qiang Zhao Bei-li Wu Zhen-lin Yang; National Natural Science Foundation of China (No. 31730027).; The chemokine receptor CCR5 is an important anti-HIV (human immunodeficiency virus) drug target owning to its pivotal role in HIV-1 viral entry as a co-receptor. Here, we present a 2.9 A resolution crystal structure o...; 关键词：CCR5 ANTI-HIV PF-232798 MARAVIROC ANTAGONIST crystal structure

A new class of HIV-1 inhibitors and the target identification via proteomic profiling被引量：1: 《Science China Chemistry》2018年第11期1430-1439,共10页Ying-Zi Ge Bin Zhou Ruo-Xuan Xiao Xiao-Jing Yuan Hu Zhou Ye-Chun Xu Mark A.Wainberg Ying-Shan Han Jian-Min Yue; supported by the National Natural Science Foundation of China (21532007, U1302222);the "Personalized Medicines-Molecular Signature-based Drug Discovery and Development";Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12020321);the Canadian Institutes for Health Research (CIHR); Anti-HIV screening with the MT-4/MTT assay on a focused library of structurally diverse natural products has led to the discovery of a group of steroids with potent activities, which include four new ergostane-type st...; 关键词：ergostane-type steroids ANTI-HIV target identification PKM2

Differential Effects of Strategies to Improve the Transduction Efficiency of Lentiviral Vector that Conveys an Anti-HIV Protein,Nullbasic,in Human T Cells: 《Virologica Sinica》2018年第2期142-152,共11页Lina Rustanti Hongping Jin Dongsheng Li Mary Lor Haran Sivakumaran David Harrich; supported by the National Health and Medical Research Council Project Grant (1085359);supported by Prime Minister’s Australia Asia Endeavour Postgraduate (Ph.D.) Award funded by the Australian Government,epartment of Education and Training,UQ international scholarship (UQI) and UQ Centenial scholarship (UQCent); Nullbasic is a mutant form of HIV-1 Tat that has strong ability to protect cells from HIV-1 replication by inhibiting three different steps of viral replication: reverse transcription, Rev export of viral m RNA from t...; 关键词：HIV-1 TRANSDUCTION Lentiviral vector Nullbasic TAT REV DDX1 lntrabody

Formulation and Solid-State Characterisation of a Novel Benzanilide Co-crystal of the Anti-HIV Drug Efavirenz: 《Journal of Pharmacy and Pharmacology》2018年第3期274-285,共12页Maryam Amra Jordaan Michael Shapi; HIV/AIDS has had a crippling socio-economic effect on developing countries in Africa. EFV （Efavirenz） is generally used to treat this pathology. However, its clinical efficacy is reduced by its limited water solubil...; 关键词：CCS EFV BZA X-ray Powder Diffraction （XRD） FTIR.

Insight into the deamination mechanism of 6-cyclopropylamino guanosine analogs for anti-HIV drug design: 《Chinese Chemical Letters》2016年第12期1759-1762,共4页Xin-Meng Fan Xian-Tao Yang Yu-Jia Guo Ren-Min Wu De-Lin Pan Zhu Guan Xiao-Mei Ling Li-He Zhang Zhen-Jun Yang; supported by National Natural Science Foundation of China (NSFC) (Nos.21172010,21002004); Deamination is a crucial step in the transformation of 6-cyclopropylamino guanosine prodrug to its active form. A convenient method using capillary electrophoresis （CE） without sample labeling was developed to analy...; 关键词：DEAMINATION 6-Cyclopropylamino guanosine Mouse liver homogenate Adenosine deaminase Anti-HIV drug design

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