云南高校图书馆联盟文献共享服务平台- DEAMINATION

DEAMINATION: 作品数：12被引量：48H指数：4; 导出分析报告; 相关领域：生物学更多>>; 相关作者：高从堦关文娟张贵清黄京飞王莹更多>>; 相关机构：中南大学北京林业大学中国科学院更多>>; 相关期刊：《Journal of Animal Science and Biotechnology》《Open Journal of Genetics》《Science China(Life Sciences)》《Advances in Biological Chemistry》更多>>; 相关基金：国家自然科学基金广东省自然科学基金更多>>

Reducing SARS-CoV-2 pathological protein activity with small molecules: 《Journal of Pharmaceutical Analysis》2021年第4期383-397,共15页Donata Pluskota-Karwatka Marcin Hoffmann Jan Barciszewski; Coronaviruses are dangerous human and animal pathogens.The newly identified coronavirus SARS-CoV-2 is the causative agent of COVID-19 outbreak,which is a real threat to human health and life.The world has been struggl...; 关键词：SARS-CoV-2 COVID-19 DEAMINATION APOBEC Therapeutic nucleotides Natural products CURCUMIN

The Pattern of Occurrence of Cytosine in the Genetic Code Minimizes Deleterious Mutations and Favors Proper Function of the Translational Machinery: 《Open Journal of Genetics》2020年第1期8-15,共8页Bin Wang; The standard genetic code consists of 64 combinations of base triplets made from four different bases. The research aim of this study was to investigate the pattern of occurrence of cytosine in the genetic code. By ex...; 关键词：Genetic Code Base TRIPLET SYNONYMS CYTOSINE DEAMINATION Translation Mutations

Does intra-ruminal nitrogen recycling waste valuable resources? A review of major players and their manipulation被引量：7: 《Journal of Animal Science and Biotechnology》2018年第3期497-517,共21页Thomas Hartinger Nina Gresner Karl-Heinz Südekum; supported by the"Deutsche Forschungsgemeinschaft"(DFG,German Research Foundation,SU124/33–1); Nitrogenous emissions from ruminant livestock production are of increasing public concern and, together with methane, contribute to environmental pollution. The main cause of nitrogen-(N)-containing emissions is the i...; 关键词：AMMONIA Bacteria DEAMINATION Hyper-ammonia producing NITROGEN efficiency Protein PROTEOLYSIS PROTOZOA Ruminant

The crystal structure of Ac-AChBP in complex with α-conotoxin LvlA reveals the mechanism of its selectivity towards different nAChR subtypes被引量：3: 《Protein & Cell》2017年第9期675-685,共11页Manyu Xu Xiaopeng Zhu Jinfang Yu Jinpeng Yu Sulan Luo Xinquan Wang; ACKNOWLEDGEMENTS We thank scientists at SSRF BL17U beam line for assistance in diffraction data collection. This work was supported by the National Natural Science Foundation of China （Grant Nos. 31470751 and U1405228 to Xinquan Wang） and the Beijing Advanced Innovation Center for Structural Biology. This work was also supported, in part, by the Major Intemational Joint Research Project of National Natural Science Foundation of China （81420108028）, and Changjiang Scholars and Innovative Research Teams in Universities Grant （IRT_I 5R15）.; The a3＊ nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous syste...; 关键词：base editor high-fidelity mouse embryos proximal-site deamination whole-genome sequencing

Effective gene editing by high-fidelity base editor 2 in mouse zygotes被引量：22: 《Protein & Cell》2017年第8期601-611,共11页Puping Liang Hongwei Sun Ying Sun Xiya Zhang Xiaowei Xie Jinran Zhang zhen Zhang Yuxi Chen Chenhui Ding Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang; This work was supported by the National Natural Science Foundation of China （Grant Nos. 91640119, 31601196, 81330055, 31371508, and 31671540）, the Natural Science Foundation of Guangdong Province （2016A030310206 and 2014A030312011）, the Science and Technology Planning Project of Guangdong Province （2015B020228002 and 2015A020212005）, the Guangzhou Science and Technology Project （201605030012 and 201707010085）, and the Fundamental Research Funds for the Central Universities （161gzd13 and 161gpy31）. We would also like to acknowledge the support of CA211653, CPRIT RP160462, the Welch Foundation Q-1673, and the C-BASS Shared Resource at the Dan L. Duncan Cancer Center （DLDCC） of Baylor College of Medicine （P30CA125123）.; Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease- causing mutations in patients. However, problems such as mosaic...; 关键词：base editor high-fidelity mouse embryos proximal-site deamination whole-genome sequencing

Insight into the deamination mechanism of 6-cyclopropylamino guanosine analogs for anti-HIV drug design: 《Chinese Chemical Letters》2016年第12期1759-1762,共4页Xin-Meng Fan Xian-Tao Yang Yu-Jia Guo Ren-Min Wu De-Lin Pan Zhu Guan Xiao-Mei Ling Li-He Zhang Zhen-Jun Yang; supported by National Natural Science Foundation of China (NSFC) (Nos.21172010,21002004); Deamination is a crucial step in the transformation of 6-cyclopropylamino guanosine prodrug to its active form. A convenient method using capillary electrophoresis （CE） without sample labeling was developed to analy...; 关键词：DEAMINATION 6-Cyclopropylamino guanosine Mouse liver homogenate Adenosine deaminase Anti-HIV drug design

Deuterium Isotope Effects in Oxidative Deamination of L-Alanine Catalyzed by L-Alanine Dehydrogenase: 《Journal of Chemistry and Chemical Engineering》2014年第2期145-150,共6页Jolanta Szymafiska Marianna Kafiska; Solvent and kinetic isotope effects in the reaction of oxidative deamination of L-alanine, catalyzed by L-alanine dehydrogenase, AIaDH, （EC 1.4.1.1） were determined using a non-competitive spectroscopic method. The ...; 关键词：L-ALANINE L-alanine dehydrogenase DEUTERIUM isotope effect pyruvate.

Precursor solution prepared by evaporation deamination complex method for solvent separation of Mo and W by H_2O_2-complexation被引量：7: 《Transactions of Nonferrous Metals Society of China》2013年第4期1139-1146,共8页关文娟张贵清高从堦; Project(2010ZX07212-008) supported by the Major Science and Technology Program for Water Pollution Control and Treatment the China Molybdenum Co., Ltd.for financial support; An novel method on preparation of precursor solution for solvent separation of molybdenum （Mo） and tungsten （W） by hydrogen peroxide （H2O2）-complexation from the ammonium tungstate solution containing high Mo wa...; 关键词：TUNGSTEN MOLYBDENUM solvent extraction separation precursor solution H202

Using the RNA synthetic activity of glutamate dehydrogenase to illuminate the natural role of the enzyme被引量：1: 《Advances in Biological Chemistry》2012年第4期379-389,共11页Godson O. Osuji Wenceslaus C. Madu; Glutamate Dehydrogenase (GDH;EC 1.4.1.2) catalyzes the reversible amination of α-ketoglutarate to glutamate, and the polymerization of nucleoside triphosphate(s) to RNA. But the natural role of the reversible aminati...; 关键词：PEANUT STOICHIOMETRIC Mineral Salt Combinations GDH Amination-Deamination Ratio Glutamate SYNTHASE Amino Acid and Protein Yields ha–1

APOBEC deaminases-mutases with defensive roles for immunity被引量：6: 《Science China(Life Sciences)》2009年第10期893-902,共10页Courtney PROCHNOW Ronda BRANSTEITTER; Supported by the National Institute of Health Grant (Grant No. R01GM087986); In recent years, tremendous progress has been made in the elucidation of the biological roles and molecular mechanisms of the apolioprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of enzymes. The A...; 关键词：APOBEC CYTIDINE DEAMINASE activation induced CYTIDINE DEAMINATION somatic HYPERMUTATION class switch recombination HyperIgM 2 syndrome human immunodeficiency virus (HIV) DNA DEAMINATION

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