HYPERMUTATION

作品数：6被引量：8H指数：2
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相关领域：医药卫生更多>>
相关作者：王辉东王建民柳红陈赛娟刘建湘更多>>
相关机构：上海交通大学医学院附属瑞金医院徐州医学院上海医科大学更多>>
相关期刊：《Science China(Life Sciences)》《Chinese Medical Journal》《Computational Molecular Bioscience》《Journal of Shanghai Jiaotong university(Science)》更多>>
相关基金：国家自然科学基金更多>>
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Antibody-Like Phosphorylation Sites. Theme for Studies of Cancer, Aging and Evolution
《Computational Molecular Bioscience》2022年第1期58-83,共26页Jaroslav Kubrycht Karel Sigler 
Sequence similarities were found between protein and DNA sequences encoding certain part of conserved variable immunoglobulin domains (i.e. conserved IgV) and phosphorylation sites. Hypermutation motifs were then indi...
关键词：Ataxia-Telangiectasia-Mutated Kinase (ATM) CARCINOGENESIS Complementarity Determining Region 1 (CDR1 Hypervariable Region 1) Conserved Domain(s) Deep Evolution EVOLUTION HYPERMUTATION Kinase(s) Phosphorylation Site(s) Plant Immunity Variable Immunoglobulin Domain(s) (IgV) 
Rigorous Running Time Analysis of a Simple Immune-Based Multi-Objective Optimizer for Bi-Objective Pseudo-Boolean Functions
《Journal of Shanghai Jiaotong university(Science)》2018年第6期827-833,共7页ZHOU Shiyuan PENG Xue WANG Yinglin XIA Xiaoyun 
the National Natural Science Foundation of China(Nos.61703183,61773410,61375053);the Public Welfare Technology Research Plan of Zhejiang Province(No.LGG19F030010)
A simple immune-based multi-objective optimizer(IBMO) is proposed, and a rigorous running time analysis of IBMO on three proposed bi-objective pseudo-Boolean functions(Bi-Trap, Bi-Plateau and Bi-Jump) is presented. Th...
关键词：evolutionary algorithm running time analysis somatic contiguous hypermutation 
Antibody-Like Phosphorylation Sites in Focus of Statistically Based Bilingual Approach被引量：2
《Computational Molecular Bioscience》2016年第1期1-22,共22页Jaroslav Kubrycht Karel Sigler Pavel Souček Jiří Hudeček 
In accordance with previous reports, the sequences related to phosporylated protein segments occur in conserved variable domains of immunoglobulins including first of all certain N-terminally located segments. Consequ...
关键词：Ataxia Telangiectasia-Mutated-Protein (i.e. Kinase ATM Whose Pathogenic Mutation Is Responsible for Early Death of People) Complementarity Determining Region 1 (of Immunoglobulins i.e. CDR1 or Hypervariable Region 1) Database (of Functional Structures) Hypermutation (i.e. Mutation of DNA Sequences Mediated by Enzymes) Immunoglobulin (i.e. Ig or Antibody) Phosphorylation (Enzyme Mediated Modification Concerns Here Mostly Protein Sequences) 
APOBEC deaminases-mutases with defensive roles for immunity被引量：6
《Science China(Life Sciences)》2009年第10期893-902,共10页Courtney PROCHNOW Ronda BRANSTEITTER 
Supported by the National Institute of Health Grant (Grant No. R01GM087986)
In recent years, tremendous progress has been made in the elucidation of the biological roles and molecular mechanisms of the apolioprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of enzymes. The A...
关键词：APOBEC CYTIDINE DEAMINASE activation induced CYTIDINE DEAMINATION somatic HYPERMUTATION class switch recombination HyperIgM 2 syndrome human immunodeficiency virus (HIV) DNA DEAMINATION 
Antiviral Warrior—APOBEC3G
《Journal of Electronic Science and Technology of China》2005年第4期372-376,共5页吴小霞 马义才 
the Cultivating Funds of Academic and Technical Leaders in Sichuan Province (No. 2200338)
This paper is to further understand how APOBEC3G can defend the retroviruses and to find new approaches to AIDs （acquired immure deficiency syndrome）.The viral infectivity factor （Vif） induces rapid degradation of...
关键词：HIV-1 CEM15/APOBEC3G VIF HYPERMUTATION innate immunity HBV 
Analysis of hypermutation of the 5' noncoding region in the BCL-6 gene
《Chinese Medical Journal》2001年第3期62-66,107,共6页王林 刘建湘 黄薇 王辉东 王建民 顾柏炜 陈竺 陈赛娟 许良中 杨文涛 金晓龙 柳红 
ThisworkwassupportedbythegrantsfromtheNationalNaturalScienceFoundationofChina (No 3 9770 83 0 ) ;andDr ClydeFoundation
ObjectiveTo investigate BCL 6 gene mutations in Chinese populations with B cell non Hodgkin's lymphoma Methods Polymerase chain reaction (PCR), denaturing gradient gel electrophoresis (DGGE) and direct DNA s...
关键词：BCL  6 gene  ·  5' noncoding region  ·  hypermutation  ·  diffuse large  cell lymphoma  ·     follicular lymphoma 
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