CYTIDINE

作品数：20被引量：49H指数：4
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相关领域：生物学医药卫生更多>>
相关作者：邱俊康肖明芳应汉杰吕浩何明芳更多>>
相关机构：中国药科大学中国科学院南京工业大学更多>>
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On the Impairment of Stress-Induced Changes in Triglyceride Levels via a Sub-Toxic Dose of Unmethylated Cytidine Phosphate Guanosine Oligodinucleotide (a Toll-Like Receptor 9 Ligand)
《Journal of Biosciences and Medicines》2024年第9期95-112,共18页Reiko Seki Kazuhisa Nishizawa 
Changes in lipid metabolism have been implicated in protection against infectious diseases. In the first experiment of this study, we measured clinical lipid parameters in a murine model where the unmethylated cytidin...
关键词：Toll-Like Receptor 9 Cytidine Phosphate Guanosine Oligodinucleotide Scavenger Receptor B1 TRIGLYCERIDE Hepatic Inflammation 
Transcriptome-wide profiling of RNA N^(4)-cytidine acetylation in Arabidopsis thaliana and Oryza sativa被引量：2
《Molecular Plant》2023年第6期1082-1098,共17页Bin Li Donghao Li Linjun Cai Qiting Zhou Cong Liu Jianzhong Lin Yixing Li Xiaoying Zhao Li Li Xuanming Liu Chongsheng He 
support from the National Natural Science Foundation of China(32070613,32270623);the Science and Technology Innovation Program of Hunan Province(2021RC3045);support from the National Natural Science Foundation of China(U20A2029);support from the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20200468).
Acetylation of N^(4)-cytidine(ac^(4)C)has recently been discovered as a novel modification of mRNA.RNA ac^(4)C modification has been shown to be a key regulator of RNA stability,RNA translation,and the thermal stress ...
关键词：N^(4)-acetylcytidine epitranscriptome Arabidopsis thaliana Oryza sativa 
Enhanced production of cytidine 5'-monophosphate using biocatalysis of di-enzymes immobilized on amino-functionalized sepharose
《Chinese Journal of Chemical Engineering》2023年第6期40-52,共13页Xiaohong Zhou Wenfeng Zhou Wei Zhuang Chenjie Zhu Hanjie Ying Hongman Zhang 
supported by grants from the National Key Research and Development Program of China(2021YFC2102805,2019YFD1101204);the National Natural Science Foundation of China(21878142,21776132);Key Research and Development Plan of Jiangsu Province(BE2020712);Key Research and Development Plan of Jiangsu Province(BE2019001);Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20190035);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Cytidine 5'-monophosphate(5'-CMP)is an essential nucleotide for additives.In this study,enhanced production of 5'-CMP was realized by the transformation of cytidine using co-immobilized di-enzymes,uridine-cytidine kin...
关键词：SEPHAROSE Ε-POLYLYSINE Dual-enzyme cascade Cytidine 5'-monophosphate Enzyme immobilization 
Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide被引量：5
《Science China(Life Sciences)》2021年第8期1355-1367,共13页Zhiquan Liu Siyu Chen Yingqi Jia Huanhuan Shan Mao Chen Yuning Song Liangxue Lai Zhanjun Li 
financially supported by the National Key Research and Development Program of China Stem Cell and Translational Research (2019YFA0110700);the Program for Changjiang Scholars and Innovative Research Team in University (IRT16R32);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030501, XDA16030503);Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110104004)
Cytidine base editor(CBE),which is composed of a cytidine deaminase fused to Cas9 nickase,has been widely used to induce C-to-T conversions in a wide range of organisms.However,the targeting scope of current CBEs is l...
关键词：BASE EDITOR compatibility 
PhieCBEs:Plant High-Efficiency Cytidine Base Editors with Expanded Target Range被引量：13
《Molecular Plant》2020年第12期1666-1669,共4页Dongchang Zeng Taoli Liu Jiantao Tan Yaling Zhang Zhiye Zheng Bin Wang Degui Zhou Xianrong Xie Menghui Guo Yao-Guang Liu Qinlong Zhu 
grants from the Major Program of Guangdong Basic and Applied Research(2019B030302006);the National Natural Science Foundation of China(31921004;31971915);the Guangdong special support program of Young Top-Notch Talent in Science and Technology Innovation(2019TQ05N147).
Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-mediated genome editing can efficiently produce gene-knockout mutants.On the other hand,CRISPR/Cas-derived base edito...
关键词：dCas9 CBE BASE 
Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice被引量：3
《The Crop Journal》2020年第3期396-402,共7页Ruiying Qin Shengxiang Liao Juan Li Hao Li Xiaoshuang Liu Jianbo Yang Pengcheng Wei 
funded by the Genetically Modified Breeding Major Project(2016ZX08010-002-008);the National Natural Science Foundation of China(31701405);the Natural Science Foundation of Anhui Province,China(1708085QC60)。
The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3(BE3) ...
关键词：CRISPR-Cas9 Base editing BE3 CDA Oryza sativa 
CRISPR-Cas nucleases and base editors for plant genome editing被引量：4
《aBIOTECH》2020年第1期74-87,共14页Filiz Gurel Yingxiao Zhang Simon Sretenovic Yiping Qi 
Our plant genome editing research is supported by the National Science Foundation Plant Genome Research Program(IOS-1758745);USDA-NIFA Biotechnology Risk Assessment Research Program(2018-33522-28789);Foundation for Food and Agriculture Research(593603);Syngenta Biotechnology.
Clustered regularly interspaced short palindromic repeats(CRISPR)—CRISPR-associated protein(Cas)and base editors are fundamental tools in plant genome editing.Cas9 from Streptococcus pyogenes(SpCas9),recognizing an N...
关键词：CRISPR SpCas9 Cas12a Cas12b PAM Cytidine/adenine base editors 
Off-target effects of cytidine base editor and adenine base editor:What can we do?
《Journal of Genetics and Genomics》2019年第11期509-512,共4页Puping Liang Jinkun Wen Junjiu Huang 
supported by the National Key R&D Program of China(2017YFC1001901);the National Natural Science Foundation(31971365 and 31601196);the Guangzhou Science and Technology Project(201803010020 and 201707010085).
DNA is the blueprint of life,instructing the growth,development,and reproduction of an organism.Genome sequencing uncovers the codes of life,whereas genome editing could rewrite the codes,thus then leads to revolution...
关键词：Off-target effects EDITOR 
DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level
《Journal of Biophysical Chemistry》2018年第3期23-40,共18页Henk M. Buck 
The new epigenetic elements 5-hydroxymethyl-dC, 5-formyl-dC, and 5-car- boxy-dC may be considered as intermediates of an active demethylation process. A comprehensive mechanistic model is given for the C-C bond cleava...
关键词：Active DEMETHYLATION DNA Catalysis Symmetry Elements (Anti)Parallel Modified DNA and RNA INHIBITION of Genetic Information 
Cytidine Mediated AuAg Nanoclusters as Bright Fluorescent Probe for Tumor Imaging in vivo被引量：2
《Chinese Journal of Chemistry》2016年第6期589-593,共5页Leifeng Chen Yuanyuan Zhang Hui Jiang Xuemei Wang Chongyang Liu 
Noble metal clusters is an emerging class of fluorescent probes, avoiding most of the drawbacks of common fluorescent compounds, and they are simple to prepare and have good water solubility, good biocompatibility and...
关键词：fluorescence bioimaging cytidine mediated AuAg nanoclusters tumor bio-labeling 
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