DEMETHYLATION

作品数：81被引量：452H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：姚宁方晓明姜朝晖方旭东张敏更多>>
相关机构：解放军第一一七医院空军军医大学（第四军医大学）江西中医药大学右江民族医学院附属医院更多>>
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Integrating multi-omics methods for personalized treatment of refractory chronic myelomonocytic leukemia with NRAS and TET2 mutations
《Cancer Pathogenesis and Therapy》2025年第2期173-175,共3页Chuandong Hou Bo Yang Yue Wang Lili Cai Ran Qin Bo Guo Jie Geng XueChun Lu 
supported by the Multi-Center Clinical Research Project of the National Clinical Research Center for Geriatric Diseases(No.NCRCG-PLAGH-20230010);the Key Military Health Project(No.23BJZ25).
Chronic myelomonocytic leukemia(CMML),a rare and malignant hematologic disorder,is classified as a myelodysplastic/myeloproliferative neoplasm(MDS/MPN).1 It poses a significant risk of progression to acute myeloid leu...
关键词：chronic myelomonocytic leukemia cmml personalized treatment demethylation therapy acute myeloid leukemia refractory chronic myelomonocytic leukemia multi omics Nras mutations Tet mutations 
Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy
《Genes & Diseases》2025年第2期113-116,共4页Yulong Li Mingzhi Shen Ting Yang Shui Yu Jianyuan Yin Leiming Luo Yali Zhao Ping Ping Shihui Fu 
supported by grants from the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital (No.2020-YQPY-007);the Natural Science Foundation of Hainan Province,China (No.821QN389,821MS117,823MS161,820MS124,821MS112,822MS198,820MS126,820QN383,822MS193);the Military Medical Science and Technology Youth Incubation Program (China) (No.20QNPY110,19QNPY060);the Key R&D Program of Hainan Province,China (No.ZDYF2023SHFZ145);the Health Care Project of PLA (China) (No.22BJZ30);the Clinical Medical Research Center Project of Hainan Province,China (LCYX202106,LCYX202201,LCYX202303);the National Key R&D Program of China (No.2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China (No.YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China (No.YSPTZX202216);the Heatstroke Treatment and Research Center of PLA (China) (No.413EGZ1D10);the Major Science and Technology Programme of Hainan Province,China (No.ZDKJ2019012).
B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,...
关键词：CARDIOMYOPATHY DILATED CARDIOVASCULAR 
High-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression during ovarian hyperstimulation in mice
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期269-285,共17页Quanmin KANG Fang LE Xiayuan XU Lifang CHEN Shi ZHENG Lijun LOU Nan JIANG Ruimin ZHAO Yuanyuan ZHOU Juan SHEN Minhao HU Ning WANG Qiongxiao HUANG Fan JIN 
supported by the National Key Research and Development Program of China(No.2018YFC1004900);the National Natural Science Foundation of China(No.82101799);the Health Science and Technology Foundation of Zhejiang Province of China(No.2022KY186).
Given that ovarian stimulation is vital for assisted reproductive technology(ART)and results in elevated serum estrogen levels,exploring the impact of elevated estrogen exposure on oocytes and embryos is necessary.We ...
关键词：Ovarian stimulation Histone methylation Assisted reproductive technology(ART) 
KDM2A and KDM2B protect a subset of CpG islands from DNA methylation
《Journal of Genetics and Genomics》2025年第1期39-50,共12页Yuan Liu Ying Liu Yunji Zhu Di Hu Hu Nie Yali Xie Rongrong Sun Jin He Honglian Zhang Falong Lu 
supported by the National Natural Science Foundation of China(32070607);the National Key Research and Development Program of China(2020YFA0804000);the CAS Project for Young Scientists in Basic Research(YSBR-012).
In the mammalian genome,most CpGs are methylated.However,CpGs within the CpG islands(CGIs)are largely unmethylated,which are important for gene expression regulation.The mechanism underlying the low methylation levels...
关键词：KDM2A KDM2B CpG island DNA methylation H3K36me2 DEMETHYLATION Embryonic stem cell 
Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state被引量：2
《Neural Regeneration Research》2024年第10期2229-2239,共11页Yubo Wang Ling Zhang Tianjie Lyu Lu Cui Shunying Zhao Xuechun Wang Meng Wang Yongjun Wang Zixiao Li 
supported by the National Natural Science Foundation of China,No.82171270 (to ZL);Public Service Platform for Artificial In telligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1 (to ZL);the Natural Science Foundation of Beijing,No.Z200016 (to ZL);Beijing Talents Project,No.2018000021223ZK03 (to ZL);Beijing Municipal Committee of Science and Technology,No.Z201 100005620010 (to ZL);CAMS Innovation Fund for Medical Sciences,No.2019-I2M-5-029 (to YongW)。
Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effec...
关键词：DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state INTERLEUKIN NEUROINFLAMMATION STROKE TET2 
FTO-mediated m^(6)A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis
《Acta Biochimica et Biophysica Sinica》2024年第10期1509-1520,共12页Tingjuan Huang Chunhong Zhang Junjie Ren Qizhi Shuai Xiaonan Li Xuewei Li Jun Xie Jun Xu 
supported by the grants from the Fundamental Research Program of Shanxi Province(No.20210302124615);the Research Fund for the Doctor Program of Shanxi Province(No.SD1913);the Research Fund for the Doctor Program of Shanxi Medical University(No.XD1913);the National Natural Science Foundation of China(No.82203221).
The activation of hepatic stellate cells(HSCs)is central to the occurrence and development of liver fibrosis.Our previous studies showed that autophagy promotes HSC activation and ultimately accelerates liver fibrosis...
关键词：AUTOPHAGY hepatic stellate cells FTO m^(6)A methylation ULK1 
The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment被引量：1
《Neuroscience Bulletin》2024年第8期1076-1092,共17页Zongyao Ren Haiyan Tang Wendiao Zhang Minghui Guo Jingjie Cui Hua Wang Bin Xie Jing Yu Yonghao Chen Ming Zhang Cong Han Tianyao Chu Qiuman Liang Shunan Zhao Yingjie Huang Xuelian He Kefu Liu Chunyu Liu Chao Chen 
supported by the National Natural Science Foundation of China(82022024,31970572,and 31871276);the National Key R&D Project of China(2016YFC1306000 and 2017YFC0908701);the Innovation-driven Project of Central South University(2020CX003);The Natural Science Foundation of Hunan Province(2023JJ40793);NIH grants(U01 MH122591,1U01MH116489,and 1R01MH110920);the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20220320).
Intellectual disability(ID)is a condition characterized by cognitive impairment and difficulties in adaptive functioning.In our research,we identified two de novo mutations(c.955C>T and c.732C>A)at the KDM2A locus in ...
关键词：Intellectual disability KDM2A Neurodevelopmental disorder Cerebral organoids 
A Label-Free Deoxyribozyme Sensor for m^(6)A Demethylase Activity Detection
《Chinese Journal of Chemistry》2024年第9期951-956,共6页Xiuyuan Wang Shusheng Yu Yuqiu He Fuan Wang Xiaoqing Liu 
supported by the Natural Science Foundation of Jiangsu Province(BK20221258);the National Natural Science Foundation of China(22274121 and 22274123).We thank Prof.Xiang Zhou at Wuhan University for CD measurement.
A label-free deoxyribozyme(DNAzyme)biosensor for m^(6) demethylase activity detection is developed.When demethylase FTO(Fat mass and obesity-associated protein),an important m^(6) demethylase of ALKBH demethylase fami...
关键词：DNAZYME Analytical methods BIOSENSING m^(6)A demethylation Fluorescence 
Observation on the Clinical Effect of Applying Venetoclax Combined with Demethylation Drug Therapy in Patients with Acute Myeloid Leukemia
《Journal of Clinical and Nursing Research》2024年第4期248-252,共5页Ben Niu Limin Hou 
Objective: To investigate the therapeutic effect of applying venetoclax combined with demethylating drugs in treating patients with acute myeloid leukemia (AML). Methods: Eighty cases of AML patients treated with vene...
关键词：Acute myeloid leukemia Venetoclax Demethylating drugs Combination therapy EFFICACY 
ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis
《World Journal of Gastroenterology》2024年第12期1764-1776,共13页Tao Zhang Shuai Zhu Geng-Wen Huang 
Supported by National Natural Science Foundation of China,No.81802450;and Natural Science Foundation of Hunan Province,No.2020JJ4133 and No.2021JJ31135.
BACKGROUND Increasing evidence has demonstrated that N6-methyladenosine(m6A)RNA modification plays an essential role in a wide range of pathological conditions.Impaired autophagy is a critical hallmark of acute pancre...
关键词：Acute pancreatitis AUTOPHAGY ZKSCAN3 N6-methyladenosine ALKBH5 
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